CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.5 | Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
|
1.20.5.740 | Single helix bin |
Domain Context
CATH Clusters
| Superfamily | Single helix bin |
| Functional Family |
Enzyme Information
| 2.2.1.6 |
Acetolactate synthase.
based on mapping to UniProt P27696
2 pyruvate = 2-acetolactate + CO(2).
-!- The reaction shown is in the pathway of biosynthesis of valine. -!- The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine. -!- Formerly EC 4.1.3.18.
|
UniProtKB Entries (1)
| P27696 |
ILVB_KLEPN
Klebsiella pneumoniae
Acetolactate synthase, catabolic
|
PDB Structure
| PDB | 1OZH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The Crystal Structures of Klebsiella pneumoniae Acetolactate Synthase with Enzyme-bound Cofactor and with an Unusual Intermediate.
J.Biol.Chem.
|
