CATH Domain 1nmkA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.100	Cyclophilin
	2.40.100.10	Cyclophilin-like

Domain Context

CATH Clusters

Superfamily	Cyclophilin-like
Functional Family	Peptidyl-prolyl cis-trans isomerase A

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt P62937

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P62937

PPIA_HUMAN

Homo sapiens

Peptidyl-prolyl cis-trans isomerase A

PDB Structure

PDB	1NMK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data Sedrani, R., Kallen, J., Cabrejas, L.M.M., Papageorgiou, C.D., Senia, F., Rohrbach, S., Wagner, D., Thai, B., Eme, A.-M.J., France, J., Oberer, L., Rihs, G., Zenke, G., Wagner, J. J.Am.Chem.Soc.