CATH Domain 1n8wA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.170	Malate synthase G - maily-beta sub-domain
	2.170.170.11	Malate synthase G - maily-beta sub-domain

Domain Context

CATH Clusters

Superfamily	Malate synthase G - maily-beta sub-domain
Functional Family

Enzyme Information

2.3.3.9

Malate synthase.

based on mapping to UniProt P9WK16

Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.

-!- The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. -!- Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2). -!- Formerly EC 4.1.3.2.

UniProtKB Entries (1)

P9WK16

MASZ_MYCTO

Mycobacterium tuberculosis CDC1551

Malate synthase G

PDB Structure

PDB	1N8W
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis Smith, C.V., Huang, C.C., Miczak, A., Russell, D.G., Sacchettini, J.C., Honer Zu Bentrup, K. J.Biol.Chem.