CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.70 | Cathepsin B; Chain A |
|
3.90.70.10 | Cysteine proteinases |
Domain Context
CATH Clusters
| Superfamily | Cysteine proteinases |
| Functional Family | Cathepsin F |
Enzyme Information
| 3.4.22.41 |
Cathepsin F.
based on mapping to UniProt Q9UBX1
The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (k(cat)/K(m)) comparable to that of cathepsin L.
-!- The enzyme is unstable at neutral pH values and is inhibited by compound E-64. -!- Belongs to peptidase family C1.
|
UniProtKB Entries (1)
| Q9UBX1 |
CATF_HUMAN
Homo sapiens
Cathepsin F
|
PDB Structure
| PDB | 1M6D |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Pichia |
| Primary Citation |
The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators
J.Mol.Biol.
|
