CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.46 | Glycine N-methyltransferase; chain A, domain 1 | |
3.30.46.10 | Glycine N-methyltransferase, chain A, domain 1 |
Domain Context
CATH Clusters
Superfamily | Glycine N-methyltransferase, chain A, domain 1 |
Functional Family | Glycine N-methyltransferase |
Enzyme Information
2.1.1.20 |
Glycine N-methyltransferase.
based on mapping to UniProt P13255
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.
-!- Thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. -!- Inhibited by 5-methyltetrahydrofolate pentaglutamate. -!- Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3.
|
UniProtKB Entries (1)
P13255 |
GNMT_RAT
Rattus norvegicus
Glycine N-methyltransferase
|
PDB Structure
PDB | 1KIA |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structure of glycine N-methyltransferase complexed with S-adenosylmethionine and acetate
To be Published
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