CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.120 | Penicillin G acylase, beta-roll domain |
|
2.30.120.10 | Aminohydrolase, N-terminal nucleophile (Ntn) domain, beta-sheet knob region |
Domain Context
CATH Clusters
| Superfamily | 2.30.120.10 |
| Functional Family |
Enzyme Information
| 3.5.1.93 |
Glutaryl-7-aminocephalosporanic-acid acylase.
based on mapping to UniProt Q9L5D6
(7R)-7-(4-carboxybutanamido)cephalosporanate + H(2)O = (7R)-7- aminocephalosporanate + glutarate.
-!- Forms 7-aminocephalosporanic acid, a key intermediate in the synthesis of cephem antibiotics. -!- It reacts only weakly with cephalosporin C.
|
UniProtKB Entries (1)
| Q9L5D6 |
G7AC_BREDI
Brevundimonas diminuta
Glutaryl-7-aminocephalosporanic-acid acylase
|
PDB Structure
| PDB | 1KEH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Precursor structure of cephalosporin acylase. Insights into autoproteolytic activation in a new N-terminal hydrolase family
J.Biol.Chem.
|
