CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
| Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
| Functional Family | Bifunctional ligase/repressor BirA |
Enzyme Information
| 6.3.4.15 |
Biotin--[biotin carboxyl-carrier protein] ligase.
based on mapping to UniProt P06709
ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N(6)-biotinyl-L-lysine.
-!- The enzyme biotinylates a biotin carboxyl-carrier protein that is part of an acetyl-CoA carboxylase complex, enabling its subsequent carboxylation by EC 6.3.4.14. -!- The carboxyl group is eventually transferred to acetyl-CoA by EC 2.1.3.15. -!- In some organisms the carrier protein is part of EC 6.4.1.2.
|
UniProtKB Entries (1)
| P06709 |
BIRA_ECOLI
Escherichia coli K-12
Bifunctional ligase/repressor BirA
|
PDB Structure
| PDB | 1HXD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Corepressor-induced organization and assembly of the biotin repressor: a model for allosteric activation of a transcriptional regulator.
Proc.Natl.Acad.Sci.USA
|
