CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.50 | Alpha/alpha barrel |
|
1.50.10 | Glycosyltransferase |
|
1.50.10.100 | Chondroitin AC/alginate lyase |
Domain Context
CATH Clusters
| Superfamily | Chondroitin AC/alginate lyase |
| Functional Family |
Enzyme Information
| 4.2.2.5 |
Chondroitin AC lyase.
based on mapping to UniProt Q59288
Eliminative degradation of polysaccharides containing 1,4-beta-D- hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups.
-!- Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate. -!- In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. -!- The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta-1- 3)GalNAc(beta-1-](n), which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. -!- GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha-1-3)GalNAc(beta-1-](n) of DS. -!- Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source. -!- Formerly EC 4.2.99.6.
|
UniProtKB Entries (1)
| Q59288 |
CSLA_PEDHD
Pedobacter heparinus DSM 2366
Chondroitinase-AC
|
PDB Structure
| PDB | 1HM2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Pedobacter |
| Primary Citation |
Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
Biochemistry
|
