CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | Dihydropyrimidine dehydrogenase [NADP(+)] |
Enzyme Information
| 1.3.1.2 |
Dihydropyrimidine dehydrogenase (NADP(+)).
based on mapping to UniProt Q28943
5,6-dihydrouracil + NADP(+) = uracil + NADPH.
-!- Also acts on dihydrothymine.
|
UniProtKB Entries (1)
| Q28943 |
DPYD_PIG
Sus scrofa
Dihydropyrimidine dehydrogenase [NADP(+)]
|
PDB Structure
| PDB | 1H7W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil.
EMBO J.
|
