CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family |
Enzyme Information
| 1.1.1.304 |
Diacetyl reductase ((S)-acetoin forming).
based on mapping to UniProt Q48436
(S)-acetoin + NAD(+) = diacetyl + NADH.
-!- The reaction is catalyzed in the reverse direction. -!- This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). -!- While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. -!- This enzyme has been reported in the bacteria Geobacillus stearothermophilus, Enterobacter aerogenes and Klebsiella pneumoniae. -!- Different from EC 1.1.1.303. -!- Formerly EC 1.1.1.5.
|
UniProtKB Entries (1)
| Q48436 |
BUDC_KLEPN
Klebsiella pneumoniae
Diacetyl reductase [(S)-acetoin forming]
|
PDB Structure
| PDB | 1GEG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of meso-2,3-butanediol dehydrogenase in a complex with NAD+ and inhibitor mercaptoethanol at 1.7 A resolution for understanding of chiral substrate recognition mechanisms.
J.Biochem.
|
