CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.479 | Tetrahydropterin Synthase; Chain A |
|
3.30.479.10 | 6-pyruvoyl tetrahydropterin synthase/QueD |
Domain Context
CATH Clusters
| Superfamily | 6-pyruvoyl tetrahydropterin synthase/QueD |
| Functional Family | 6-pyruvoyl tetrahydrobiopterin synthase |
Enzyme Information
| 4.2.3.12 |
6-pyruvoyltetrahydropterin synthase.
based on mapping to UniProt P27213
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8- tetrahydropterin + triphosphate.
-!- Catalyzes triphosphate elimination and an intramolecular redox reaction. -!- The product is 6-pyruvoyltetrahydrobiopterin. -!- Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 3.5.4.16. -!- Formerly EC 4.6.1.10.
|
UniProtKB Entries (1)
| P27213 |
PTPS_RAT
Rattus norvegicus
6-pyruvoyl tetrahydrobiopterin synthase
|
PDB Structure
| PDB | 1B66 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.
J.Mol.Biol.
|
