CATH Superfamily 6.10.140.2210
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 1: Putative e3 ubiquitin-protein ligase hakai
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
8 | M9PBE2 (/ISS) Q4R7I8 (/ISS) Q4R7I8 (/ISS) Q4V7X9 (/ISS) Q5ZHZ4 (/ISS) Q75N03 (/ISS) Q75N03 (/ISS) Q75N03 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | Q75N03 (/IPI) Q75N03 (/IPI) Q75N03 (/IPI) Q9JIY2 (/IPI) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
3 | Q75N03 (/TAS) Q75N03 (/TAS) Q75N03 (/TAS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | M9PBE2 (/ISM) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q9JIY2 (/IPI) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
1 | M9PBE2 (/IPI) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q9JIY2 (/IDA) |
There are 23 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
|
7 | Q4R7I8 (/ISS) Q4R7I8 (/ISS) Q4V7X9 (/ISS) Q5ZHZ4 (/ISS) Q75N03 (/ISS) Q75N03 (/ISS) Q75N03 (/ISS) |
|
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
7 | Q4R7I8 (/ISS) Q4R7I8 (/ISS) Q4V7X9 (/ISS) Q5ZHZ4 (/ISS) Q75N03 (/ISS) Q75N03 (/ISS) Q75N03 (/ISS) |
|
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
|
7 | Q4R7I8 (/ISS) Q4R7I8 (/ISS) Q4V7X9 (/ISS) Q5ZHZ4 (/ISS) Q75N03 (/ISS) Q75N03 (/ISS) Q75N03 (/ISS) |
|
MRNA methylation GO:0080009
The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.
|
4 | Q4R7I8 (/ISS) Q4R7I8 (/ISS) Q4V7X9 (/ISS) Q5ZHZ4 (/ISS) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
3 | Q75N03 (/TAS) Q75N03 (/TAS) Q75N03 (/TAS) |
|
Entry of bacterium into host cell GO:0035635
The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
3 | Q75N03 (/TAS) Q75N03 (/TAS) Q75N03 (/TAS) |
|
MRNA methylation GO:0080009
The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.
|
3 | Q75N03 (/IMP) Q75N03 (/IMP) Q75N03 (/IMP) |
|
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
|
3 | Q75N03 (/IDA) Q75N03 (/IDA) Q75N03 (/IDA) |
|
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
|
1 | M9PBE2 (/IMP) |
|
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
|
1 | Q9JIY2 (/IDA) |
|
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
|
1 | M9PBE2 (/IMP) |
|
Epithelial cell migration, open tracheal system GO:0007427
The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster.
|
1 | M9PBE2 (/IMP) |
|
Midgut development GO:0007494
The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.
|
1 | M9PBE2 (/IMP) |
|
Head involution GO:0008258
Movement of the anterior ectoderm to the interior of the embryo.
|
1 | M9PBE2 (/IMP) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | M9PBE2 (/IDA) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | M9PBE2 (/ISS) |
|
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
1 | Q9JIY2 (/IDA) |
|
Segmentation GO:0035282
The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.
|
1 | M9PBE2 (/IMP) |
|
Chitin-based cuticle development GO:0040003
Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster.
|
1 | M9PBE2 (/IMP) |
|
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
|
1 | Q9JIY2 (/IDA) |
|
Epithelium development GO:0060429
The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
|
1 | M9PBE2 (/IMP) |
|
MRNA methylation GO:0080009
The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.
|
1 | Q9JIY2 (/ISO) |
|
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
|
1 | Q9JIY2 (/ISO) |
There are 14 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
7 | Q4R7I8 (/ISS) Q4R7I8 (/ISS) Q4V7X9 (/ISS) Q5ZHZ4 (/ISS) Q75N03 (/ISS) Q75N03 (/ISS) Q75N03 (/ISS) |
|
RNA N6-methyladenosine methyltransferase complex GO:0036396
A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).
|
5 | M9PBE2 (/IDA) Q75N03 (/IDA) Q75N03 (/IDA) Q75N03 (/IDA) Q9JIY2 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q4R7I8 (/ISS) Q4R7I8 (/ISS) Q4V7X9 (/ISS) Q5ZHZ4 (/ISS) |
|
RNA N6-methyladenosine methyltransferase complex GO:0036396
A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).
|
4 | Q4R7I8 (/ISS) Q4R7I8 (/ISS) Q4V7X9 (/ISS) Q5ZHZ4 (/ISS) |
|
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
3 | Q75N03 (/IC) Q75N03 (/IC) Q75N03 (/IC) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q75N03 (/TAS) Q75N03 (/TAS) Q75N03 (/TAS) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
3 | Q75N03 (/IDA) Q75N03 (/IDA) Q75N03 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9JIY2 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9JIY2 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | M9PBE2 (/IDA) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q9JIY2 (/ISO) |
|
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
1 | M9PBE2 (/IDA) |
|
RNA N6-methyladenosine methyltransferase complex GO:0036396
A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).
|
1 | Q9JIY2 (/ISO) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | M9PBE2 (/IDA) |
