The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aminolevulinic Acid Synthase 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: 5-aminolevulinate synthase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
7 P08680 (/ISS) P08680 (/ISS) Q3ZC31 (/ISS) Q5R557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS)
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
2 P22557 (/IDA) Q63147 (/IDA)
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
2 P08680 (/IMP) P08680 (/IMP)
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
2 P08680 (/ISO) P08680 (/ISO)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
2 P08680 (/ISO) P08680 (/ISO)
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
2 P08680 (/ISO) P08680 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P22557 (/IPI)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
1 Q63147 (/IDA)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
1 P22557 (/ISS)
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
1 Q63147 (/IDA)
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
1 P22557 (/ISS)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
7 P08680 (/ISS) P08680 (/ISS) Q3ZC31 (/ISS) Q5R557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
4 P22557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
4 P22557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS)
Hemoglobin biosynthetic process GO:0042541
The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
4 P22557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 P08680 (/ISO) P08680 (/ISO)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
2 P08680 (/IMP) P08680 (/IMP)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
2 P08680 (/IMP) P08680 (/IMP)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
2 P08680 (/IMP) P08680 (/IMP)
Hemoglobin biosynthetic process GO:0042541
The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
2 P08680 (/IMP) P08680 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P22557 (/IDA)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q63147 (/IEP)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
1 P22557 (/NAS)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
1 P22557 (/TAS)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 P22557 (/ISS)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
1 Q63147 (/IEP)
Response to lead ion GO:0010288
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
1 Q63147 (/IEP)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
1 P22557 (/NAS)
Response to cobalt ion GO:0032025
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus.
1 Q63147 (/IEP)
Oxygen homeostasis GO:0032364
A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell.
1 P22557 (/NAS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q63147 (/IEP)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
1 Q63147 (/IEP)
Response to fatty acid GO:0070542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
1 Q63147 (/IEP)
Liver regeneration GO:0097421
The regrowth of lost or destroyed liver.
1 Q63147 (/IEP)
Response to benzene GO:1901423
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzene stimulus.
1 Q63147 (/IEP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
7 P08680 (/ISS) P08680 (/ISS) Q3ZC31 (/ISS) Q5R557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 P08680 (/ISS) P08680 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P08680 (/HDA) P08680 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P22557 (/IDA) Q63147 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P08680 (/ISO) P08680 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 P08680 (/ISO) P08680 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P22557 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P22557 (/TAS)
CATH-Gene3D is a Global Biodata Core Resource Learn more...