The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome c oxidase, subunit VIIa
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Cytochrome c oxidase subunit 7A1, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytochrome-c oxidase activity GO:0004129
Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
8 O14548 (/TAS) O14548 (/TAS) O14548 (/TAS) O14548 (/TAS) O14548 (/TAS) O14548 (/TAS) P24310 (/TAS) P24310 (/TAS)
Cytochrome-c oxidase activity GO:0004129
Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
5 P56392 (/ISS) P56392 (/ISS) Q9VHR9 (/ISS) Q9VHS2 (/ISS) Q9VHS2 (/ISS)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial electron transport, cytochrome c to oxygen GO:0006123
The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV.
6 O14548 (/TAS) O14548 (/TAS) O14548 (/TAS) O14548 (/TAS) O14548 (/TAS) O14548 (/TAS)
Regulation of oxidative phosphorylation GO:0002082
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
3 Q61387 (/IMP) Q61387 (/IMP) Q61387 (/IMP)
Mitochondrial electron transport, cytochrome c to oxygen GO:0006123
The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV.
3 Q9VHR9 (/ISS) Q9VHS2 (/ISS) Q9VHS2 (/ISS)
Mitochondrial respirasome assembly GO:0097250
The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex.
3 Q61387 (/IDA) Q61387 (/IDA) Q61387 (/IDA)
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
2 P24310 (/TAS) P24310 (/TAS)
Regulation of oxidative phosphorylation GO:0002082
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
1 Q3T061 (/ISS)
Mitochondrial respirasome assembly GO:0097250
The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex.
1 Q3T061 (/ISS)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
12 O14548 (/IDA) O14548 (/IDA) O14548 (/IDA) O14548 (/IDA) O14548 (/IDA) O14548 (/IDA) Q6FGA0 (/IDA) Q6FGA0 (/IDA) Q6FGA0 (/IDA) Q6FGA0 (/IDA)
(2 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
12 O14548 (/IDA) O14548 (/IDA) O14548 (/IDA) O14548 (/IDA) O14548 (/IDA) O14548 (/IDA) Q6FGA0 (/IDA) Q6FGA0 (/IDA) Q6FGA0 (/IDA) Q6FGA0 (/IDA)
(2 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
9 P48771 (/HDA) P48771 (/HDA) P56392 (/HDA) P56392 (/HDA) Q61387 (/HDA) Q61387 (/HDA) Q61387 (/HDA) Q9VHS2 (/HDA) Q9VHS2 (/HDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
6 O14548 (/TAS) O14548 (/TAS) O14548 (/TAS) O14548 (/TAS) O14548 (/TAS) O14548 (/TAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
3 Q61387 (/ISO) Q61387 (/ISO) Q61387 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 Q61387 (/ISO) Q61387 (/ISO) Q61387 (/ISO)
Mitochondrial respirasome GO:0005746
The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.
3 Q61387 (/IDA) Q61387 (/IDA) Q61387 (/IDA)
Mitochondrial respiratory chain complex IV GO:0005751
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
3 Q9VHR9 (/ISS) Q9VHS2 (/ISS) Q9VHS2 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P07470 (/ISS) Q8SPJ9 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P24310 (/TAS) P24310 (/TAS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 P48771 (/HDA) P48771 (/HDA)
Mitochondrial respirasome GO:0005746
The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.
1 Q3T061 (/ISS)
Respiratory chain complex IV GO:0045277
A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
1 P07470 (/IDA)
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