The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Capsid protein VP4 superfamily, Picornavirus
".
FunFam 2: Genome polyprotein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
RNA-directed 5'-3' RNA polymerase activity GO:0003968
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
|
1 | P03304 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P03304 (/IPI) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Induction by virus of host autophagy GO:0039520
Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host.
|
8 | P03304 (/ISS) P08544 (/ISS) P08545 (/ISS) P12296 (/ISS) P13899 (/ISS) P17593 (/ISS) P17594 (/ISS) Q66765 (/ISS) |
|
Suppression by virus of host RIG-I activity GO:0039540
Any process in which a virus stops, prevents, or reduces the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
|
3 | Q155Z9 (/IDA) Q155Z9 (/IDA) Q66765 (/IDA) |
|
Suppression by virus of host RIG-I signaling pathway GO:0039538
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. This is a mechanism by which the virus evades the host innate immune response.
|
2 | Q155Z9 (/IDA) Q155Z9 (/IDA) |
|
Suppression by virus of host TBK1 activity GO:0039723
Any process in which a virus stops, prevents, or reduces the activity of the host serine/threonine kinase TBK1.
|
2 | Q155Z9 (/IDA) Q155Z9 (/IDA) |
|
Induction by virus of host autophagy GO:0039520
Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host.
|
1 | Q1KNJ5 (/IDA) |
|
Suppression by virus of host mRNA export from nucleus GO:0039522
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of movement of mRNA from the nucleus to the cytoplasm in the host organism.
|
1 | C0MHL9 (/IDA) |
|
Positive stranded viral RNA replication GO:0039690
A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA.
|
1 | P12296 (/IDA) |
There are 0 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
