The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Thyroglobulin type-1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 8: tumor-associated calcium signal transducer 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P09758 (/IPI) P09758 (/IPI) P16422 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P16422 (/IDA)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of epithelial cell migration GO:0010633
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
9 F1S7A4 (/ISS) F7GC38 (/ISS) F7GC38 (/ISS) G1L072 (/ISS) G1S9N6 (/ISS) G3I680 (/ISS) P09758 (/ISS) P09758 (/ISS) Q6P9Z6 (/ISS)
Negative regulation of stress fiber assembly GO:0051497
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
9 F1S7A4 (/ISS) F7GC38 (/ISS) F7GC38 (/ISS) G1L072 (/ISS) G1S9N6 (/ISS) G3I680 (/ISS) P09758 (/ISS) P09758 (/ISS) Q6P9Z6 (/ISS)
Negative regulation of branching involved in ureteric bud morphogenesis GO:0090191
Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
9 F1S7A4 (/ISS) F7GC38 (/ISS) F7GC38 (/ISS) G1L072 (/ISS) G1S9N6 (/ISS) G3I680 (/ISS) P09758 (/ISS) P09758 (/ISS) Q6P9Z6 (/ISS)
Negative regulation of substrate adhesion-dependent cell spreading GO:1900025
Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.
9 F1S7A4 (/ISS) F7GC38 (/ISS) F7GC38 (/ISS) G1L072 (/ISS) G1S9N6 (/ISS) G3I680 (/ISS) P09758 (/ISS) P09758 (/ISS) Q6P9Z6 (/ISS)
Negative regulation of ruffle assembly GO:1900028
Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.
9 F1S7A4 (/ISS) F7GC38 (/ISS) F7GC38 (/ISS) G1L072 (/ISS) G1S9N6 (/ISS) G3I680 (/ISS) P09758 (/ISS) P09758 (/ISS) Q6P9Z6 (/ISS)
Negative regulation of cell motility GO:2000146
Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.
9 F1S7A4 (/ISS) F7GC38 (/ISS) F7GC38 (/ISS) G1L072 (/ISS) G1S9N6 (/ISS) G3I680 (/ISS) P09758 (/ISS) P09758 (/ISS) Q6P9Z6 (/ISS)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
4 B8JM11 (/IGI) Q568H0 (/IGI) Q6DRJ5 (/IGI) Q6NY70 (/IGI)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
4 B8JM11 (/IMP) Q568H0 (/IMP) Q6DRJ5 (/IMP) Q6NY70 (/IMP)
Morphogenesis of an epithelium GO:0002009
The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
4 B8JM11 (/IMP) Q568H0 (/IMP) Q6DRJ5 (/IMP) Q6NY70 (/IMP)
Posterior lateral line neuromast primordium migration GO:0048920
The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop.
4 B8JM11 (/IGI) Q568H0 (/IGI) Q6DRJ5 (/IGI) Q6NY70 (/IGI)
Epiboly involved in gastrulation with mouth forming second GO:0055113
The expansion of one cell sheet over other cells involved in deuterostomic gastrulation.
4 B8JM11 (/IGI) Q568H0 (/IGI) Q6DRJ5 (/IGI) Q6NY70 (/IGI)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
4 B8JM11 (/IGI) Q568H0 (/IGI) Q6DRJ5 (/IGI) Q6NY70 (/IGI)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
2 P09758 (/TAS) P09758 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 Q1WER1 (/ISS) Q1WER1 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P16422 (/IDA)
Negative regulation of epithelial cell migration GO:0010633
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
1 Q8BGV3 (/IDA)
Signal transduction involved in regulation of gene expression GO:0023019
Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.
1 P16422 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P16422 (/IDA)
Stem cell differentiation GO:0048863
The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
1 P16422 (/IMP)
Regulation of epithelial cell proliferation GO:0050678
Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
1 Q8BGV3 (/IEP)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
1 P16422 (/TAS)
Negative regulation of stress fiber assembly GO:0051497
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
1 Q8BGV3 (/IDA)
Ureteric bud morphogenesis GO:0060675
The process in which the ureteric bud is generated and organized.
1 Q8BGV3 (/IEP)
Negative regulation of branching involved in ureteric bud morphogenesis GO:0090191
Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
1 Q8BGV3 (/IDA)
Negative regulation of substrate adhesion-dependent cell spreading GO:1900025
Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.
1 Q8BGV3 (/IDA)
Negative regulation of ruffle assembly GO:1900028
Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.
1 Q8BGV3 (/IDA)
Negative regulation of cell-cell adhesion mediated by cadherin GO:2000048
Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin.
1 P16422 (/IDA)
Negative regulation of cell motility GO:2000146
Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.
1 Q8BGV3 (/IDA)
Positive regulation of stem cell proliferation GO:2000648
Any process that activates or increases the frequency, rate or extent of stem cell proliferation.
1 P16422 (/IMP)
Positive regulation of stem cell differentiation GO:2000738
Any process that activates or increases the frequency, rate or extent of stem cell differentiation.
1 Q8BGV3 (/IDA)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
11 F1S7A4 (/ISS) F7GC38 (/ISS) F7GC38 (/ISS) G1L072 (/ISS) G1S9N6 (/ISS) G3I680 (/ISS) P09758 (/ISS) P09758 (/ISS) Q1WER1 (/ISS) Q1WER1 (/ISS)
(1 more)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
9 F1S7A4 (/ISS) F7GC38 (/ISS) F7GC38 (/ISS) G1L072 (/ISS) G1S9N6 (/ISS) G3I680 (/ISS) P09758 (/ISS) P09758 (/ISS) Q6P9Z6 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 B5MCA4 (/IDA) B8JM11 (/IDA) P16422 (/IDA) Q568H0 (/IDA) Q6DRJ5 (/IDA) Q6NY70 (/IDA) Q8BGV3 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
5 B8JM11 (/IDA) P16422 (/IDA) Q568H0 (/IDA) Q6DRJ5 (/IDA) Q6NY70 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 B8JM11 (/IDA) Q568H0 (/IDA) Q6DRJ5 (/IDA) Q6NY70 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P09758 (/HDA) P09758 (/HDA) P16422 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P09758 (/TAS) P09758 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q1WER1 (/ISS) Q1WER1 (/ISS)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
2 Q1WER1 (/ISS) Q1WER1 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P09758 (/TAS) P09758 (/TAS)
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
2 P16422 (/IDA) Q8BGV3 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q8BGV3 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8BGV3 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P16422 (/TAS)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
1 P16422 (/IDA)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q8BGV3 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8BGV3 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 P16422 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...