The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Thyroglobulin type-1
".
FunFam 6: testican-1 isoform X2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cysteine-type endopeptidase inhibitor activity GO:0004869
Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Serine-type endopeptidase inhibitor activity GO:0004867
Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
|
1 | Q08629 (/NAS) |
Cysteine-type endopeptidase inhibitor activity GO:0004869
Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
|
1 | Q08629 (/IDA) |
Cysteine-type endopeptidase inhibitor activity GO:0004869
Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
|
1 | Q62288 (/ISO) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | Q08629 (/IDA) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | Q62288 (/ISO) |
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
|
1 | Q08629 (/IDA) |
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
|
1 | Q62288 (/ISO) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Negative regulation of cell-substrate adhesion GO:0010812
Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Central nervous system neuron differentiation GO:0021953
The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Neurogenesis GO:0022008
Generation of cells within the nervous system.
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
|
1 | Q08629 (/NAS) |
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
1 | Q62288 (/IEP) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | Q08629 (/NAS) |
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
1 | Q08629 (/NAS) |
Negative regulation of cell-substrate adhesion GO:0010812
Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
|
1 | Q08629 (/IDA) |
Negative regulation of cell-substrate adhesion GO:0010812
Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
|
1 | Q62288 (/ISO) |
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
|
1 | Q08629 (/IDA) |
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
|
1 | Q62288 (/ISO) |
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | Q08629 (/IDA) |
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | Q62288 (/ISO) |
Central nervous system neuron differentiation GO:0021953
The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.
|
1 | Q62288 (/IEP) |
Neurogenesis GO:0022008
Generation of cells within the nervous system.
|
1 | Q62288 (/IEP) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Sarcoplasm GO:0016528
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Node of Ranvier GO:0033268
An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
|
13 |
A0A2I3HGL0 (/ISS)
F1NW71 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7B8Z2 (/ISS)
F7I1V8 (/ISS)
G1MC50 (/ISS)
G1N7F0 (/ISS)
(3 more) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q08629 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q62288 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q62288 (/IDA) |
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
1 | Q08629 (/NAS) |
Sarcoplasm GO:0016528
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
|
1 | Q62288 (/IDA) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
1 | Q62288 (/IDA) |
Node of Ranvier GO:0033268
An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
|
1 | Q62288 (/IDA) |