The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Agouti domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Agouti-related peptide 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Type 1 melanocortin receptor binding GO:0070996
Interacting selectively and non-covalently with a type 1 melanocortin receptor.
4 A0A2R8PWU9 (/IDA) A0A2R8QM92 (/IDA) E9QBS3 (/IDA) J3JQX9 (/IDA)
Neuropeptide hormone activity GO:0005184
The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.
3 A0A2R8PWU9 (/IDA) A0A2R8QM92 (/IDA) E9QBS3 (/IDA)
Type 3 melanocortin receptor binding GO:0031781
Interacting selectively and non-covalently with a type 3 melanocortin receptor.
3 A0A2R8PWU9 (/IDA) A0A2R8QM92 (/IDA) E9QBS3 (/IDA)
Type 4 melanocortin receptor binding GO:0031782
Interacting selectively and non-covalently with a type 4 melanocortin receptor.
3 A0A2R8PWU9 (/IDA) A0A2R8QM92 (/IDA) E9QBS3 (/IDA)
Hormone activity GO:0005179
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
1 F1MAG1 (/TAS)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of feeding behavior GO:2000253
Any process that activates or increases the frequency, rate or extent of feeding behavior.
4 A0A2R8PWU9 (/IMP) A0A2R8QM92 (/IMP) E9QBS3 (/IMP) F1MAG1 (/IMP)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
3 A0A2R8PWU9 (/IDA) A0A2R8QM92 (/IDA) E9QBS3 (/IDA)
Regulation of growth GO:0040008
Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
3 A0A2R8PWU9 (/IGI) A0A2R8QM92 (/IGI) E9QBS3 (/IGI)
Developmental growth GO:0048589
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
3 A0A2R8PWU9 (/IGI) A0A2R8QM92 (/IGI) E9QBS3 (/IGI)
Developmental growth GO:0048589
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
3 A0A2R8PWU9 (/IMP) A0A2R8QM92 (/IMP) E9QBS3 (/IMP)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
1 F1MAG1 (/IEP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 F1MAG1 (/IEP)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
1 F1MAG1 (/TAS)
Adult feeding behavior GO:0008343
Feeding behavior in a fully developed and mature organism.
1 F1MAG1 (/IEP)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 F1MAG1 (/IEP)
Eating behavior GO:0042755
The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
1 F1MAG1 (/IMP)
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
1 J3JQX9 (/IMP)
Long-day photoperiodism GO:0048571
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length.
1 F1MAG1 (/IEP)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
1 F1MAG1 (/IEP)
Positive regulation of feeding behavior GO:2000253
Any process that activates or increases the frequency, rate or extent of feeding behavior.
1 F1MAG1 (/IDA)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 F1MAG1 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 F1MAG1 (/TAS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 F1MAG1 (/IDA)
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