The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Disintegrin domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Disintegrin and metalloproteinase domain-containin...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 45 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
24 F8VQ03 (/IPI) O35674 (/IPI) O35674 (/IPI) O75077 (/IPI) O75077 (/IPI) O75077 (/IPI) O88839 (/IPI) P78325 (/IPI) Q05910 (/IPI) Q05910 (/IPI)
(14 more)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
14 O43184 (/TAS) O43506 (/TAS) O75077 (/TAS) O75077 (/TAS) O75077 (/TAS) O75078 (/TAS) Q13444 (/TAS) Q99965 (/TAS) Q9UKF2 (/TAS) Q9UKF5 (/TAS)
(4 more)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
8 A3R0T9 (/IDA) P86092 (/IDA) Q13443 (/IDA) Q400M8 (/IDA) Q61072 (/IDA) Q6QU65 (/IDA) Q86P79 (/IDA) Q8T3I9 (/IDA)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
8 P78325 (/IDA) Q05910 (/IDA) Q05910 (/IDA) Q13444 (/IDA) Q7ZYZ9 (/IDA) Q8JIR2 (/IDA) Q9PSN7 (/IDA) Q9UKQ2 (/IDA)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
7 O75077 (/TAS) O75077 (/TAS) O75077 (/TAS) O75078 (/TAS) Q05910 (/TAS) Q05910 (/TAS) Q99965 (/TAS)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
5 A8QL48 (/ISS) A8QL49 (/ISS) A8QL59 (/ISS) O35674 (/ISS) O35674 (/ISS)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
5 O88839 (/ISO) Q05910 (/ISO) Q05910 (/ISO) Q61072 (/ISO) Q9JLN6 (/ISO)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
4 Q9R157 (/ISS) Q9R158 (/ISS) Q9R159 (/ISS) Q9R160 (/ISS)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
4 G5EFD5 (/ISS) Q9R158 (/ISS) Q9R159 (/ISS) Q9R160 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
4 A3R0T9 (/TAS) P78325 (/TAS) Q8JIR2 (/TAS) Q9UKF2 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 Q400M8 (/IPI) Q6QU65 (/IPI) Q86P79 (/IPI) Q8T3I9 (/IPI)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
3 O35674 (/ISO) O35674 (/ISO) Q61072 (/ISO)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
3 P70505 (/NAS) Q60813 (/NAS) Q60813 (/NAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 Q05910 (/IDA) Q05910 (/IDA) Q10749 (/IDA)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
3 O43184 (/IPI) Q13443 (/IPI) Q13444 (/IPI)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
3 O88839 (/ISO) Q61072 (/ISO) Q61824 (/ISO)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
3 P78325 (/IPI) Q05910 (/IPI) Q05910 (/IPI)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2 Q13443 (/IMP) Q9H013 (/IMP)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
2 O88839 (/ISO) Q61072 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q05910 (/IDA) Q05910 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 P78325 (/ISS) Q9W6M5 (/ISS)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
2 O35674 (/IMP) O35674 (/IMP)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
2 Q05910 (/ISO) Q05910 (/ISO)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 Q7ZYZ9 (/IPI)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 O35227 (/IDA)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 Q9QYV0 (/TAS)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 P78325 (/TAS)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
1 Q61072 (/IPI)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
1 Q13443 (/ISS)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q13443 (/IC)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q13443 (/IDA)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q13444 (/IMP)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q13443 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q9P0K1 (/NAS)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
1 Q13443 (/IMP)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
1 Q61072 (/ISO)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 Q10749 (/IDA)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 Q13443 (/IMP)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 O13766 (/ISM)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q9W6M5 (/ISS)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
1 Q61072 (/IDA)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
1 Q13443 (/ISS)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
1 Q13443 (/IMP)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
1 Q61072 (/ISO)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
1 P78325 (/TAS)

There are 189 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane protein ectodomain proteolysis GO:0006509
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
13 B7Z0Y2 (/ISS) M9NDY9 (/ISS) M9NH46 (/ISS) M9PER2 (/ISS) M9PH86 (/ISS) Q400M8 (/ISS) Q6QU65 (/ISS) Q7KUY7 (/ISS) Q86P79 (/ISS) Q8T3I9 (/ISS)
(3 more)
Membrane protein ectodomain proteolysis GO:0006509
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
8 O35674 (/IDA) O35674 (/IDA) Q13443 (/IDA) Q400M8 (/IDA) Q61072 (/IDA) Q6QU65 (/IDA) Q86P79 (/IDA) Q8T3I9 (/IDA)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
8 A0A0G2JX23 (/IEP) G3V9N4 (/IEP) P70505 (/IEP) P70534 (/IEP) P70535 (/IEP) Q5BK84 (/IEP) Q63202 (/IEP) Q9QYV0 (/IEP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
4 Q9UKF5 (/TAS) Q9UKF5 (/TAS) Q9UKQ2 (/TAS) Q9Y3Q7 (/TAS)
Binding of sperm to zona pellucida GO:0007339
The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.
4 O43506 (/TAS) Q99965 (/TAS) Q9UKF2 (/TAS) Q9UKJ8 (/TAS)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
4 O75077 (/TAS) O75077 (/TAS) O75077 (/TAS) Q9P0K1 (/TAS)
Positive regulation of membrane protein ectodomain proteolysis GO:0051044
Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.
4 P78325 (/IDA) Q05910 (/IDA) Q05910 (/IDA) Q61072 (/IDA)
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
4 Q400M8 (/IDA) Q6QU65 (/IDA) Q86P79 (/IDA) Q8T3I9 (/IDA)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
3 P70505 (/NAS) Q60813 (/NAS) Q60813 (/NAS)
Membrane protein ectodomain proteolysis GO:0006509
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
3 O35674 (/IMP) O35674 (/IMP) Q13443 (/IMP)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
3 Q05910 (/TAS) Q05910 (/TAS) Q13444 (/TAS)
Binding of sperm to zona pellucida GO:0007339
The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.
3 F8VQ03 (/IMP) Q60813 (/IMP) Q60813 (/IMP)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
3 O43184 (/TAS) Q13444 (/TAS) Q9H013 (/TAS)
Envenomation resulting in hemorrhagic damage to other organism GO:0044358
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with vascular damage and hemorrhage in the bitten organism.
3 A8QL48 (/ISS) A8QL49 (/ISS) A8QL59 (/ISS)
Envenomation resulting in negative regulation of platelet aggregation in other organism GO:0044477
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of platelet aggregation in the bitten organism.
3 A8QL48 (/ISS) A8QL49 (/ISS) A8QL59 (/ISS)
Envenomation resulting in proteolysis in other organism GO:0044481
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant hydrolysis of proteins in of the bitten organism.
3 A8QL48 (/ISS) A8QL49 (/ISS) A8QL59 (/ISS)
Envenomation resulting in fibrinogenolysis in other organism GO:0044485
The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinogenolysis, a process that degrades fibrinogen at a variety of Arg-Lys bonds, thus impairing fibrinogen clotting in the bloodstream of the bitten/stung organism.
3 A8QL48 (/ISS) A8QL49 (/ISS) A8QL59 (/ISS)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
2 Q05910 (/IMP) Q05910 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 Q05910 (/IDA) Q05910 (/IDA)
Placenta development GO:0001890
The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
2 O35674 (/ISS) O35674 (/ISS)
Leukocyte migration involved in inflammatory response GO:0002523
The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
2 Q05910 (/IMP) Q05910 (/IMP)
Positive regulation of acute inflammatory response GO:0002675
Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
2 Q05910 (/IMP) Q05910 (/IMP)
Positive regulation of cellular extravasation GO:0002693
Any process that activates or increases the frequency, rate, or extent of cellular extravasation.
2 Q05910 (/IMP) Q05910 (/IMP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 Q05910 (/ISO) Q05910 (/ISO)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q13443 (/IMP) Q61072 (/IMP)
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
2 O43506 (/TAS) Q9UKJ8 (/TAS)
Fusion of sperm to egg plasma membrane involved in single fertilization GO:0007342
The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.
2 Q60813 (/NAS) Q60813 (/NAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 O35674 (/IMP) O35674 (/IMP)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
2 Q9R1V6 (/IMP) Q9R1V6 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 F8VQ03 (/IMP) Q60718 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 O35674 (/ISO) O35674 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 O35674 (/ISS) O35674 (/ISS)
Schwann cell differentiation GO:0014037
The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
2 Q9R1V6 (/IMP) Q9R1V6 (/IMP)
Myelination in peripheral nervous system GO:0022011
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
2 Q9R1V6 (/IMP) Q9R1V6 (/IMP)
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
2 Q05910 (/ISO) Q05910 (/ISO)
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
2 Q05910 (/ISS) Q05910 (/ISS)
Extracellular matrix disassembly GO:0022617
A process that results in the breakdown of the extracellular matrix.
2 P78325 (/TAS) Q13444 (/TAS)
Positive regulation of T cell differentiation in thymus GO:0033089
Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus.
2 Q05910 (/IDA) Q05910 (/IDA)
Response to laminar fluid shear stress GO:0034616
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls.
2 E9PTA4 (/IEP) Q58GH6 (/IEP)
Gliogenesis GO:0042063
The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.
2 Q9R1V6 (/IGI) Q9R1V6 (/IGI)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
2 Q05910 (/IDA) Q05910 (/IDA)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
2 Q05910 (/IDA) Q05910 (/IDA)
Blood vessel endothelial cell migration GO:0043534
The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis.
2 Q05910 (/NAS) Q05910 (/NAS)
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
2 Q05910 (/IDA) Q05910 (/IDA)
Regulation of osteoclast differentiation GO:0045670
Any process that modulates the frequency, rate or extent of osteoclast differentiation.
2 Q05910 (/NAS) Q05910 (/NAS)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
2 Q05910 (/IDA) Q05910 (/IDA)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
2 Q05910 (/IMP) Q05910 (/IMP)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
2 Q05910 (/IDA) Q05910 (/IDA)
Lymphocyte chemotaxis GO:0048247
The directed movement of a lymphocyte in response to an external stimulus.
2 Q05910 (/IDA) Q05910 (/IDA)
Tissue morphogenesis GO:0048729
The process in which the anatomical structures of a tissue are generated and organized.
2 Q05910 (/TAS) Q05910 (/TAS)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
2 Q05910 (/IDA) Q05910 (/IDA)
Positive regulation of membrane protein ectodomain proteolysis GO:0051044
Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.
2 Q05910 (/ISO) Q05910 (/ISO)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
2 Q05910 (/IDA) Q05910 (/IDA)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 Q05910 (/IDA) Q05910 (/IDA)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
2 Q05910 (/TAS) Q05910 (/TAS)
Positive regulation of thymocyte apoptotic process GO:0070245
Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process.
2 Q05910 (/IMP) Q05910 (/IMP)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 Q05910 (/ISO) Q05910 (/ISO)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 Q05910 (/ISS) Q05910 (/ISS)
Osteoclast fusion GO:0072675
The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast.
2 Q05910 (/TAS) Q05910 (/TAS)
Response to antineoplastic agent GO:0097327
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms.
2 E9PTA4 (/IEP) Q58GH6 (/IEP)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
2 Q05910 (/IDA) Q05910 (/IDA)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
2 G5EFD5 (/TAS) Q9QYV0 (/TAS)
Neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645
A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
2 Q9R1V6 (/IMP) Q9R1V6 (/IMP)
Positive regulation of cell-cell adhesion mediated by cadherin GO:2000049
Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin.
2 O35674 (/ISO) O35674 (/ISO)
Positive regulation of cell-cell adhesion mediated by cadherin GO:2000049
Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin.
2 O35674 (/ISS) O35674 (/ISS)
Positive regulation of tumor necrosis factor (ligand) superfamily member 11 production GO:2000309
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production.
2 Q05910 (/IMP) Q05910 (/IMP)
Positive regulation of neutrophil extravasation GO:2000391
Any process that activates or increases the frequency, rate or extent of neutrophil extravasation.
2 Q05910 (/ISO) Q05910 (/ISO)
Negative regulation of thymocyte aggregation GO:2000399
Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte aggregation.
2 Q05910 (/NAS) Q05910 (/NAS)
Positive regulation of T cell migration GO:2000406
Any process that activates or increases the frequency, rate or extent of T cell migration.
2 Q05910 (/IMP) Q05910 (/IMP)
Positive regulation of fibronectin-dependent thymocyte migration GO:2000415
Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration.
2 Q05910 (/IMP) Q05910 (/IMP)
Positive regulation of eosinophil migration GO:2000418
Any process that activates or increases the frequency, rate or extent of eosinophil migration.
2 Q05910 (/IMP) Q05910 (/IMP)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
1 Q13443 (/IDA)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
1 Q61072 (/ISO)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
1 P78325 (/ISS)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 P78325 (/ISS)
Placenta development GO:0001890
The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
1 Q9H013 (/IEP)
Negative regulation of cell-matrix adhesion GO:0001953
Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.
1 Q13444 (/IMP)
Negative regulation of cell-matrix adhesion GO:0001953
Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.
1 O88839 (/ISO)
Immune response to tumor cell GO:0002418
An immune system process that functions in the response of an organism to a tumor cell.
1 Q13444 (/IDA)
Immune response to tumor cell GO:0002418
An immune system process that functions in the response of an organism to a tumor cell.
1 O88839 (/ISO)
Leukocyte migration involved in inflammatory response GO:0002523
The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
1 P78325 (/ISS)
Positive regulation of acute inflammatory response GO:0002675
Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
1 P78325 (/ISS)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 Q8JIR2 (/IDA)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 G5EFD5 (/ISS)
Membrane protein ectodomain proteolysis GO:0006509
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
1 Q61072 (/ISO)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P78325 (/IDA)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q60718 (/IGI)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q13443 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q61072 (/ISO)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
1 Q13443 (/IMP)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
1 Q61072 (/ISO)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
1 Q9P0K1 (/NAS)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q61072 (/ISO)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q13443 (/ISS)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q13443 (/IC)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q13444 (/IMP)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O88839 (/ISO)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O75078 (/TAS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q63202 (/IEP)
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
1 F8VQ03 (/IGI)
Binding of sperm to zona pellucida GO:0007339
The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.
1 F8VQ03 (/IDA)
Fusion of sperm to egg plasma membrane involved in single fertilization GO:0007342
The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.
1 Q99965 (/TAS)
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 O43184 (/TAS)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 P86092 (/IDA)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 Q9PSN7 (/TAS)
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
1 Q60718 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 P86092 (/IDA)
Fertilization GO:0009566
The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
1 F8VQ03 (/IMP)
Response to manganese ion GO:0010042
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
1 Q13443 (/IMP)
Response to manganese ion GO:0010042
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
1 Q61072 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9H013 (/IDA)
Positive regulation of protein processing GO:0010954
Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.
1 P78325 (/NAS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 Q61072 (/IDA)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 Q13443 (/ISS)
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
1 P78325 (/IDA)
Negative regulation of blood coagulation GO:0030195
Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.
1 Q10749 (/IDA)
Keratinocyte differentiation GO:0030216
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
1 Q13443 (/IEP)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 Q13444 (/IMP)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 O88839 (/ISO)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 F8VQ03 (/IMP)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 Q13444 (/IMP)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 O88839 (/ISO)
Ascospore wall assembly GO:0030476
The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae.
1 O13766 (/IMP)
Adult behavior GO:0030534
Behavior in a fully developed and mature organism.
1 Q60718 (/IMP)
Positive regulation of T cell differentiation in thymus GO:0033089
Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus.
1 P78325 (/ISS)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
1 Q61072 (/IDA)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
1 Q13443 (/IMP)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
1 Q61072 (/ISO)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
1 Q13443 (/ISS)
Positive regulation of cell adhesion mediated by integrin GO:0033630
Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.
1 Q13443 (/IMP)
Positive regulation of cell adhesion mediated by integrin GO:0033630
Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.
1 Q61072 (/ISO)
Cell-cell adhesion mediated by integrin GO:0033631
The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
1 Q13443 (/IEP)
Positive regulation of macrophage fusion GO:0034241
Any process that activates or increases the frequency, rate or extent of macrophage fusion.
1 Q13443 (/IMP)
Positive regulation of macrophage fusion GO:0034241
Any process that activates or increases the frequency, rate or extent of macrophage fusion.
1 Q61072 (/ISO)
Response to tumor necrosis factor GO:0034612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q13443 (/IDA)
Response to tumor necrosis factor GO:0034612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q61072 (/ISO)
Monocyte activation GO:0042117
The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 Q13443 (/IMP)
Monocyte activation GO:0042117
The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 Q61072 (/ISO)
Tissue regeneration GO:0042246
The regrowth of lost or destroyed tissues.
1 Q9QYV0 (/IEP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q13443 (/IMP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q61072 (/ISO)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 P78325 (/TAS)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
1 P78325 (/ISS)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 P78325 (/ISS)
Envenomation resulting in hemorrhagic damage to other organism GO:0044358
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with vascular damage and hemorrhage in the bitten organism.
1 A3R0T9 (/IDA)
Envenomation resulting in negative regulation of platelet aggregation in other organism GO:0044477
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of platelet aggregation in the bitten organism.
1 A3R0T9 (/IDA)
Envenomation resulting in proteolysis in other organism GO:0044481
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant hydrolysis of proteins in of the bitten organism.
1 A3R0T9 (/IDA)
Envenomation resulting in fibrinogenolysis in other organism GO:0044485
The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinogenolysis, a process that degrades fibrinogen at a variety of Arg-Lys bonds, thus impairing fibrinogen clotting in the bloodstream of the bitten/stung organism.
1 A3R0T9 (/IDA)
Plasma membrane fusion GO:0045026
The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.
1 G5EFD5 (/TAS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 Q13444 (/IDA)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 O88839 (/ISO)
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 P78325 (/ISS)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 O43184 (/IMP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 Q61824 (/ISO)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
1 P78325 (/ISS)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 P78325 (/ISS)
Lymphocyte chemotaxis GO:0048247
The directed movement of a lymphocyte in response to an external stimulus.
1 P78325 (/ISS)
Regulation of mRNA processing GO:0050684
Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.
1 F8VQ03 (/IMP)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 P78325 (/IC)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q13443 (/IDA)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q61072 (/ISO)
Positive regulation of membrane protein ectodomain proteolysis GO:0051044
Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.
1 Q13443 (/ISS)
PMA-inducible membrane protein ectodomain proteolysis GO:0051088
The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist.
1 Q61072 (/ISO)
PMA-inducible membrane protein ectodomain proteolysis GO:0051088
The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist.
1 Q13443 (/TAS)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 P78325 (/ISS)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 Q61072 (/IMP)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 Q13443 (/ISS)
Positive regulation of keratinocyte migration GO:0051549
Any process that activates or increases the frequency, rate or extent of keratinocyte migration.
1 Q13443 (/IMP)
Positive regulation of keratinocyte migration GO:0051549
Any process that activates or increases the frequency, rate or extent of keratinocyte migration.
1 Q61072 (/ISO)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 Q13443 (/IMP)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 Q61072 (/ISO)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 P78325 (/ISS)
Cardiac epithelial to mesenchymal transition GO:0060317
A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 O88839 (/IMP)
Prevention of polyspermy GO:0060468
The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg.
1 Q9R160 (/IMP)
Positive regulation of thymocyte apoptotic process GO:0070245
Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process.
1 P78325 (/ISS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q13443 (/IMP)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q61072 (/ISO)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P78325 (/IDA)
Negative regulation of receptor binding GO:1900121
Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.
1 Q13444 (/IMP)
Negative regulation of receptor binding GO:1900121
Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.
1 O88839 (/ISO)
Cellular response to phorbol 13-acetate 12-myristate GO:1904628
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus.
1 Q13444 (/IDA)
Cellular response to phorbol 13-acetate 12-myristate GO:1904628
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus.
1 O88839 (/ISO)
Cellular response to leukemia inhibitory factor GO:1990830
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
1 Q9R1V7 (/IEP)
Response to hypobaric hypoxia GO:1990910
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level).
1 Q9QYV0 (/IEP)
Positive regulation of cell-cell adhesion mediated by cadherin GO:2000049
Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin.
1 Q9H013 (/IDA)
Positive regulation of tumor necrosis factor (ligand) superfamily member 11 production GO:2000309
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production.
1 P78325 (/ISS)
Positive regulation of neutrophil extravasation GO:2000391
Any process that activates or increases the frequency, rate or extent of neutrophil extravasation.
1 P78325 (/IDA)
Positive regulation of fibronectin-dependent thymocyte migration GO:2000415
Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration.
1 P78325 (/ISS)
Positive regulation of eosinophil migration GO:2000418
Any process that activates or increases the frequency, rate or extent of eosinophil migration.
1 P78325 (/ISS)

There are 88 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
14 O43184 (/TAS) O43506 (/TAS) O75077 (/TAS) O75077 (/TAS) O75077 (/TAS) O75078 (/TAS) P78325 (/TAS) Q13444 (/TAS) Q61824 (/TAS) Q99965 (/TAS)
(4 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
14 B7Z0Y2 (/ISS) M9NDY9 (/ISS) M9NH46 (/ISS) M9PER2 (/ISS) M9PH86 (/ISS) Q400M8 (/ISS) Q6QU65 (/ISS) Q7KUY7 (/ISS) Q86P79 (/ISS) Q8T3I9 (/ISS)
(4 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 F8VQ03 (/IDA) O35227 (/IDA) O43184 (/IDA) P78325 (/IDA) Q05910 (/IDA) Q05910 (/IDA) Q61072 (/IDA) Q9JLN6 (/IDA) Q9P0K1 (/IDA) Q9UKQ2 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
10 B2RSY5 (/IDA) E9PTA4 (/IDA) F8VQ03 (/IDA) P78325 (/IDA) Q13444 (/IDA) Q32NZ3 (/IDA) Q58GH6 (/IDA) Q60718 (/IDA) Q61072 (/IDA) Q8CGQ1 (/IDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
9 B2RSY5 (/IDA) Q32NZ3 (/IDA) Q60815 (/IDA) Q811Q3 (/IDA) Q811Q4 (/IDA) Q8CGQ1 (/IDA) Q8CGQ2 (/IDA) Q9R158 (/IDA) Q9R160 (/IDA)
Sperm head plasma membrane GO:1990913
The plasma membrane that is part of the head section of a sperm cell.
9 B2RSY5 (/IDA) Q32NZ3 (/IDA) Q60815 (/IDA) Q811Q3 (/IDA) Q811Q4 (/IDA) Q8CGQ1 (/IDA) Q8CGQ2 (/IDA) Q9R158 (/IDA) Q9R160 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 Q05910 (/ISO) Q05910 (/ISO) Q61824 (/ISO) Q9JLN6 (/ISO) Q9R1V6 (/ISO) Q9R1V6 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
6 O75077 (/TAS) O75077 (/TAS) O75077 (/TAS) Q99965 (/TAS) Q9UKF5 (/TAS) Q9UKF5 (/TAS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
5 B2RSY5 (/IDA) F8VQ03 (/IDA) Q32NZ3 (/IDA) Q60718 (/IDA) Q8CGQ1 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 O88839 (/ISO) Q05910 (/ISO) Q05910 (/ISO) Q61072 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P70505 (/NAS) Q60813 (/NAS) Q60813 (/NAS) Q9P0K1 (/NAS)
Perivitelline space GO:0098595
The space between the membrane of an oocyte and a surrounding membranous structure (zona pellucida or perivitelline membrane).
4 Q400M8 (/HDA) Q6QU65 (/HDA) Q86P79 (/HDA) Q8T3I9 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 O88839 (/HDA) Q61072 (/HDA) Q61824 (/HDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
3 Q9JI76 (/IDA) Q9R1V6 (/IDA) Q9R1V6 (/IDA)
Extracellular space of host GO:0043655
The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream.
3 A8QL48 (/ISS) A8QL49 (/ISS) A8QL59 (/ISS)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
3 F8VQ03 (/IDA) Q60813 (/IDA) Q60813 (/IDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
3 O35674 (/HDA) O35674 (/HDA) Q9H013 (/HDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
3 Q9R1V6 (/IDA) Q9R1V6 (/IDA) Q9R1V7 (/IDA)
Podosome GO:0002102
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
2 Q05910 (/ISO) Q05910 (/ISO)
Podosome GO:0002102
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
2 Q05910 (/ISS) Q05910 (/ISS)
Podosome GO:0002102
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
2 Q05910 (/TAS) Q05910 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P86092 (/IDA) Q10749 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O35674 (/ISO) O35674 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O35674 (/ISS) O35674 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P78325 (/IDA) Q61072 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q05910 (/ISO) Q05910 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q05910 (/ISS) Q05910 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 O35674 (/IDA) O35674 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q05910 (/ISO) Q05910 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q05910 (/ISS) Q05910 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9R1V6 (/IDA) Q9R1V6 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 E9PTA4 (/IDA) Q58GH6 (/IDA)
Phagolysosome GO:0032010
A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.
2 Q05910 (/ISO) Q05910 (/ISO)
Phagolysosome GO:0032010
A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.
2 Q05910 (/ISS) Q05910 (/ISS)
Dense core granule membrane GO:0032127
The lipid bilayer surrounding a dense core granule.
2 Q05910 (/ISO) Q05910 (/ISO)
Dense core granule membrane GO:0032127
The lipid bilayer surrounding a dense core granule.
2 Q05910 (/ISS) Q05910 (/ISS)
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
2 Q05910 (/ISO) Q05910 (/ISO)
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
2 Q05910 (/ISS) Q05910 (/ISS)
Tertiary granule GO:0070820
A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells.
2 Q05910 (/ISO) Q05910 (/ISO)
Tertiary granule GO:0070820
A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells.
2 Q05910 (/ISS) Q05910 (/ISS)
Alpha9-beta1 integrin-ADAM8 complex GO:0071133
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8.
2 Q05910 (/IDA) Q05910 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 Q9R1V6 (/IMP) Q9R1V6 (/IMP)
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9R1V6 (/IDA) Q9R1V6 (/IDA)
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9R1V6 (/IMP) Q9R1V6 (/IMP)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
1 Q63202 (/IDA)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
1 Q60718 (/ISO)
Podosome GO:0002102
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
1 P78325 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q9W6M5 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q61072 (/IMP)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q61072 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q13443 (/ISS)
Ascospore wall GO:0005619
The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi.
1 O13766 (/HDA)
Ascospore wall GO:0005619
The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi.
1 O13766 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9H013 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O43184 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q61824 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9UKQ2 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9JLN6 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 O13766 (/HDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 O13766 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P78325 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q13443 (/HDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q13443 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 G5EFD5 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9Y3Q7 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9UKF2 (/TAS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q61072 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q9P0K1 (/ISS)
Intrinsic component of external side of plasma membrane GO:0031233
The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor.
1 Q61072 (/IDA)
Intrinsic component of external side of plasma membrane GO:0031233
The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor.
1 Q13443 (/ISS)
Phagolysosome GO:0032010
A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.
1 P78325 (/IDA)
Dense core granule membrane GO:0032127
The lipid bilayer surrounding a dense core granule.
1 P78325 (/IDA)
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
1 P78325 (/TAS)
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
1 P78325 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q9JI76 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9JI76 (/IDA)
Extracellular space of host GO:0043655
The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream.
1 A3R0T9 (/NAS)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q63180 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 O35227 (/ISO)
Sperm head GO:0061827
The part of the late spermatid or spermatozoon that contains the nucleus and acrosome.
1 F8VQ03 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q13443 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q13444 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O88839 (/ISO)
Tertiary granule GO:0070820
A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells.
1 P78325 (/IDA)
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
1 P78325 (/TAS)
Alpha9-beta1 integrin-ADAM8 complex GO:0071133
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8.
1 P78325 (/ISS)
Integral component of presynaptic membrane GO:0099056
The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9R1V7 (/IDA)
Ficolin-1-rich granule membrane GO:0101003
The lipid bilayer surrounding a ficolin-1-rich granule.
1 P78325 (/TAS)