The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Zinc finger, CCHC-type
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: cellular nucleic acid-binding protein-like isoform...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
114 E9QBN6 (/IDA) F1Q6Z5 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA)
(104 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
111 P62633 (/IPI) P62633 (/IPI) P62633 (/IPI) P62633 (/IPI) P62633 (/IPI) P62633 (/IPI) P62633 (/IPI) P62633 (/IPI) P62633 (/IPI) P62633 (/IPI)
(101 more)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
110 P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA)
(100 more)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
110 P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA)
(100 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
110 P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS)
(100 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
110 P62633 (/HDA) P62633 (/HDA) P62633 (/HDA) P62633 (/HDA) P62633 (/HDA) P62633 (/HDA) P62633 (/HDA) P62633 (/HDA) P62633 (/HDA) P62633 (/HDA)
(100 more)
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
110 P62634 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA) P62634 (/IDA)
(100 more)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
48 P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO)
(38 more)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
48 P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO)
(38 more)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
48 P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO)
(38 more)
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
48 P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO)
(38 more)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
4 E9QBN6 (/IDA) F1Q6Z5 (/IDA) Q6PGX7 (/IDA) Q801Z9 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 E9QBN6 (/IDA) F1Q6Z5 (/IDA) Q6PGX7 (/IDA) Q801Z9 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 P36627 (/ISO)
Translation activator activity GO:0008494
Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide.
1 P36627 (/ISO)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
440 P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS)
(430 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
440 P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS)
(430 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
440 P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS)
(430 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
110 P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA) P62633 (/IDA)
(100 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
110 P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS)
(100 more)
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
110 P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS) P62633 (/TAS)
(100 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
52 E9QBN6 (/IDA) F1Q6Z5 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA)
(42 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
48 P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO) P53996 (/ISO)
(38 more)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
48 P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA)
(38 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
48 P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA)
(38 more)
Neural crest formation GO:0014029
The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.
4 E9QBN6 (/IMP) F1Q6Z5 (/IMP) Q6PGX7 (/IMP) Q801Z9 (/IMP)
Neural crest cell fate specification GO:0014036
The process in which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
4 E9QBN6 (/IMP) F1Q6Z5 (/IMP) Q6PGX7 (/IMP) Q801Z9 (/IMP)
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
4 E9QBN6 (/IMP) F1Q6Z5 (/IMP) Q6PGX7 (/IMP) Q801Z9 (/IMP)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
4 E9QBN6 (/IMP) F1Q6Z5 (/IMP) Q6PGX7 (/IMP) Q801Z9 (/IMP)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
4 E9QBN6 (/IMP) F1Q6Z5 (/IMP) Q6PGX7 (/IMP) Q801Z9 (/IMP)
Head development GO:0060322
The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.
4 E9QBN6 (/IMP) F1Q6Z5 (/IMP) Q6PGX7 (/IMP) Q801Z9 (/IMP)
Positive regulation of cytoplasmic translation GO:2000767
Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.
1 P36627 (/ISO)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
440 P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS)
(430 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
440 P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS)
(430 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
440 P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS) P62633 (/ISS)
(430 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
48 P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA)
(38 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
48 P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA)
(38 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
48 P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA) P53996 (/IDA)
(38 more)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P36627 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P36627 (/HDA)
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