The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Low-density Lipoprotein Receptor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 140: Terribly reduced optic lobes, isoform AF

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cargo receptor activity GO:0038024
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
1 Q6X0I2 (/IDA)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Defasciculation of motor neuron axon GO:0007415
Separation of a motor axon away from a bundle of axons known as a fascicle.
11 E1JJC0 (/IMP) M9NDL5 (/IMP) M9NE56 (/IMP) M9NES6 (/IMP) M9NFS1 (/IMP) Q8IRV8 (/IMP) Q8MPN3 (/IMP) Q9NEF9 (/IMP) Q9W4Y3 (/IMP) Q9W4Y4 (/IMP)
(1 more)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
11 E1JJC0 (/IMP) M9NDL5 (/IMP) M9NE56 (/IMP) M9NES6 (/IMP) M9NFS1 (/IMP) Q8IRV8 (/IMP) Q8MPN3 (/IMP) Q9NEF9 (/IMP) Q9W4Y3 (/IMP) Q9W4Y4 (/IMP)
(1 more)
Maintenance of epithelial cell apical/basal polarity GO:0045199
The maintenance of the apicobasal polarity of an epithelial cell.
11 E1JJC0 (/IMP) M9NDL5 (/IMP) M9NE56 (/IMP) M9NES6 (/IMP) M9NFS1 (/IMP) Q8IRV8 (/IMP) Q8MPN3 (/IMP) Q9NEF9 (/IMP) Q9W4Y3 (/IMP) Q9W4Y4 (/IMP)
(1 more)
Response to anesthetic GO:0072347
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation.
11 E1JJC0 (/IMP) M9NDL5 (/IMP) M9NE56 (/IMP) M9NES6 (/IMP) M9NFS1 (/IMP) Q8IRV8 (/IMP) Q8MPN3 (/IMP) Q9NEF9 (/IMP) Q9W4Y3 (/IMP) Q9W4Y4 (/IMP)
(1 more)
Positive regulation of semaphorin-plexin signaling pathway GO:2001262
Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway.
11 E1JJC0 (/IGI) M9NDL5 (/IGI) M9NE56 (/IGI) M9NES6 (/IGI) M9NFS1 (/IGI) Q8IRV8 (/IGI) Q8MPN3 (/IGI) Q9NEF9 (/IGI) Q9W4Y3 (/IGI) Q9W4Y4 (/IGI)
(1 more)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
1 Q6X0I2 (/IDA)
Negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037
Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
1 Q9W4Y3 (/IGI)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
3 M9NFS1 (/ISS) Q8MPN3 (/ISS) Q9NEF9 (/ISS)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 Q9W4Y3 (/IDA)
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