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CATH Superfamily 4.10.375.10

Lipoxygenase-1; Domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Lipoxygenase-1; Domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Lipoxygenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Linoleate 13S-lipoxygenase. [EC: 1.13.11.12]
(1) Linoleate + O(2) = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate. (2) Alpha-linolenate + O(2) = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca- 9,11,15-trienoate.
  • A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(13) position with (S)- configuration.
  • This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid.
  • EC 1.13.11.58 catalyzes a similar reaction at the second available position of these fatty acids.
  • Formerly EC 1.13.1.13 and EC 1.99.2.1.
 13 A0A178W1Z8 A0A178W1Z8 O24370 O24371 P38419 P38419 Q0J4K2 Q0J4K2 Q84YK8 Q9CAG3
(3 more...)
Linoleate 9S-lipoxygenase. [EC: 1.13.11.58]
Linoleate + O(2) = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.
  • A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(9) position with (S)- configuration.
  • The enzyme plays a physiological role during the early stages of seedling growth.
  • The enzyme from Arabidopsis thaliana shows comparable activity toward linoleate and linolenate.
  • EC 1.13.11.12 catalyzes a similar reaction at another position of these fatty acids.
 12 O22507 O22508 O24379 P29250 P37831 P38415 Q06327 Q41238 Q43189 Q43190
(2 more...)
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