The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
E3-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Dihydrolipoamide acetyltransferase component of py...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dihydrolipoyl dehydrogenase activity GO:0004148
Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
7 P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P9WIS7 (/IPI) P9WIS7 (/IPI) P9WIS7 (/IPI) P9WIS7 (/IPI) P9WIS7 (/IPI) P9WIS7 (/IPI) P9WIS7 (/IPI)
Disulfide oxidoreductase activity GO:0015036
Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
7 P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS)
Lipoic acid binding GO:0031405
Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid.
7 P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA)
Dihydrolipoamide branched chain acyltransferase activity GO:0004147
Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain.
2 A0A0F7RCC3 (/ISS) A0A0F7RCC3 (/ISS)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
7 P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
7 P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
7 P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS)
Branched-chain amino acid catabolic process GO:0009083
The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
2 A0A0F7RCC3 (/ISS) A0A0F7RCC3 (/ISS)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
7 P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS) P9WIS7 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA) P9WIS7 (/HDA)
Pyruvate dehydrogenase complex GO:0045254
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).
7 P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA) P9WIS7 (/IDA)
3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex GO:0017086
A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate.
2 A0A0F7RCC3 (/ISS) A0A0F7RCC3 (/ISS)
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