The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Zn(2)-C6 fungal-type DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 75: Transcriptional regulatory protein moc3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
2 O74308 (/ISM) Q9UT46 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 O74308 (/NAS) Q9UT46 (/NAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 Q5A4F3 (/IMP) Q5A4F3 (/IMP)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 O74308 (/ISM) Q9UT46 (/ISM)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q5A4F3 (/IDA) Q5A4F3 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9UT46 (/IPI)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
3 Q5A4F3 (/IMP) Q5A4F3 (/IMP) Q5ANB1 (/IMP)
Invasive growth in response to glucose limitation GO:0001403
A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
2 Q5A4F3 (/IGI) Q5A4F3 (/IGI)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
2 Q5A4F3 (/IMP) Q5A4F3 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
2 Q5A4F3 (/IMP) Q5A4F3 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 Q5A4F3 (/IMP) Q5A4F3 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
2 Q5A4F3 (/IMP) Q5A4F3 (/IMP)
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
2 Q5A4F3 (/IMP) Q5A4F3 (/IMP)
Cell adhesion involved in single-species biofilm formation GO:0043709
The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
2 Q5A4F3 (/IMP) Q5A4F3 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q5A4F3 (/IGI) Q5A4F3 (/IGI)
Positive regulation of cell adhesion involved in single-species biofilm formation GO:1900189
Any process that activates or increases the frequency, rate or extent of cell adhesion involved in single-species biofilm formation.
2 Q5A4F3 (/IMP) Q5A4F3 (/IMP)
Regulation of phenotypic switching GO:1900239
Any process that modulates the frequency, rate or extent of phenotypic switching.
2 Q5A4F3 (/IMP) Q5A4F3 (/IMP)
Regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:1900443
Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus.
2 Q5A4F3 (/IMP) Q5A4F3 (/IMP)
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
2 Q5A4F3 (/IMP) Q5A4F3 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O74308 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9UT46 (/NAS)
Positive regulation of conjugation with cellular fusion GO:0031139
Any process that increases the rate or frequency of conjugation with cellular fusion.
1 Q9UT46 (/IGI)
Positive regulation of conjugation with cellular fusion GO:0031139
Any process that increases the rate or frequency of conjugation with cellular fusion.
1 Q9UT46 (/IMP)
Phenotypic switching GO:0036166
A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
1 Q5ANB1 (/IMP)
Galactose-specific flocculation GO:0036349
The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other.
1 O74308 (/IMP)
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
1 O74308 (/IEP)
Negative regulation of flocculation GO:0060257
Any process that decreases the rate, frequency or extent of the non-sexual aggregation of single-celled organisms.
1 O74308 (/IMP)
Growth of unicellular organism as a thread of attached cells GO:0070783
A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions.
1 Q5ANB1 (/IMP)
Negative regulation of growth of unicellular organism as a thread of attached cells GO:0070785
Any process that decreases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium.
1 Q5ANB1 (/IMP)
Positive regulation of phenotypic switching GO:1900241
Any process that activates or increases the frequency, rate or extent of phenotypic switching.
1 Q5ANB1 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O74308 (/HDA) Q9UT46 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O74308 (/IDA) Q9UT46 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q5A4F3 (/IGI) Q5A4F3 (/IGI)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 O74308 (/IDA)
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