The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Zinc finger, RanBP2-type
".
FunFam 9: YY1 associated factor 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
46 |
Q8CCI5 (/IPI)
Q8CCI5 (/IPI)
Q8IY57 (/IPI)
Q8IY57 (/IPI)
Q8IY57 (/IPI)
Q8IY57 (/IPI)
Q8IY57 (/IPI)
Q8IY57 (/IPI)
Q8IY57 (/IPI)
Q8IY57 (/IPI)
(36 more) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
23 |
Q8CCI5 (/IDA)
Q8CCI5 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
(13 more) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
22 |
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
(12 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
21 |
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
(11 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
8 | Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q99LW6 (/ISS) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
8 | Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q99LW6 (/ISS) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
3 | Q8CCI5 (/IDA) Q8CCI5 (/IDA) Q9W215 (/IDA) |
There are 22 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of G0 to G1 transition GO:0070317
A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.
|
43 |
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
(33 more) |
|
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
22 |
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
Q8N488 (/TAS)
(12 more) |
|
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435
Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
22 |
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
(12 more) |
|
Histone H2A monoubiquitination GO:0035518
The modification of histone H2A by addition of a single ubiquitin group.
|
22 |
Q8N488 (/IDA)
Q8N488 (/IDA)
Q8N488 (/IDA)
Q8N488 (/IDA)
Q8N488 (/IDA)
Q8N488 (/IDA)
Q8N488 (/IDA)
Q8N488 (/IDA)
Q8N488 (/IDA)
Q8N488 (/IDA)
(12 more) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
22 |
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
(12 more) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
22 |
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
Q8N488 (/IMP)
(12 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
21 |
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
(11 more) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
21 |
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
(11 more) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
10 | Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q8CCI5 (/ISS) Q8CCI5 (/ISS) Q99LW6 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
8 | Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q99LW6 (/ISS) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
4 | Q1JPU4 (/IMP) Q5SP48 (/IMP) Q5SP49 (/IMP) Q9W215 (/IMP) |
|
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
|
3 | Q1JPU4 (/IMP) Q5SP48 (/IMP) Q5SP49 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q8CCI5 (/IDA) Q8CCI5 (/IDA) |
|
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435
Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
2 | Q8CCI5 (/ISO) Q8CCI5 (/ISO) |
|
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435
Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
2 | Q8CCI5 (/ISS) Q8CCI5 (/ISS) |
|
Histone H2A monoubiquitination GO:0035518
The modification of histone H2A by addition of a single ubiquitin group.
|
2 | Q8CCI5 (/ISO) Q8CCI5 (/ISO) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
2 | Q8CCI5 (/ISO) Q8CCI5 (/ISO) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
2 | Q8CCI5 (/ISS) Q8CCI5 (/ISS) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q8CCI5 (/ISO) Q8CCI5 (/ISO) |
|
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
|
1 | Q9W215 (/IGI) |
|
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
|
1 | Q9W215 (/IPI) |
|
Negative regulation of immune response GO:0050777
Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
1 | Q9W215 (/IMP) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
46 |
Q8CCI5 (/IDA)
Q8CCI5 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
(36 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
45 |
Q8CCI5 (/IDA)
Q8CCI5 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
(35 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
43 |
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
Q8IY57 (/TAS)
(33 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
21 |
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
Q8IY57 (/IDA)
(11 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q5ZKC5 (/ISS) Q99LW6 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q8CCI5 (/ISO) Q8CCI5 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q8CCI5 (/ISO) Q8CCI5 (/ISO) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | Q9W215 (/IDA) |