The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Zinc finger, RanBP2-type
".
FunFam 15: Nuclear pore complex protein Nup153
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 20 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Nuclear localization sequence binding GO:0008139
Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Protein membrane anchor GO:0043495
Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific membrane location.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P49790 (/IPI) P49791 (/IPI) |
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | P49791 (/IDA) |
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
1 | P49791 (/IDA) |
Nuclear localization sequence binding GO:0008139
Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
|
1 | P49791 (/IDA) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | P49791 (/IDA) |
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
|
1 | P49791 (/IPI) |
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
|
1 | P49790 (/IDA) |
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
|
1 | P49790 (/IMP) |
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
|
1 | P49791 (/ISS) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P49790 (/IPI) |
Protein membrane anchor GO:0043495
Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific membrane location.
|
1 | P49790 (/IMP) |
Protein membrane anchor GO:0043495
Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific membrane location.
|
1 | P49791 (/ISS) |
There are 17 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Negative regulation of RNA export from nucleus GO:0046832
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Nuclear pore complex assembly GO:0051292
The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
|
1 | P49791 (/IDA) |
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
|
1 | P49790 (/TAS) |
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
|
1 | P49790 (/TAS) |
TRNA export from nucleus GO:0006409
The directed movement of tRNA from the nucleus to the cytoplasm.
|
1 | P49790 (/TAS) |
Viral process GO:0016032
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
|
1 | P49790 (/TAS) |
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
1 | P49790 (/TAS) |
Viral transcription GO:0019083
The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.
|
1 | P49790 (/TAS) |
Negative regulation of RNA export from nucleus GO:0046832
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm.
|
1 | P49790 (/IDA) |
Negative regulation of RNA export from nucleus GO:0046832
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm.
|
1 | P49791 (/ISS) |
Nuclear pore complex assembly GO:0051292
The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex.
|
1 | P49790 (/IMP) |
Nuclear pore complex assembly GO:0051292
The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex.
|
1 | P49791 (/ISS) |
Regulation of gene silencing by miRNA GO:0060964
Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: RNA (often mRNA) cleavage or mRNA translational repression.
|
1 | P49790 (/TAS) |
Intracellular transport of virus GO:0075733
The directed movement of a virus, or part of a virus, within the host cell.
|
1 | P49790 (/TAS) |
Regulation of cellular response to heat GO:1900034
Any process that modulates the frequency, rate or extent of cellular response to heat.
|
1 | P49790 (/TAS) |
There are 24 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Annulate lamellae GO:0005642
Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Nuclear inclusion body GO:0042405
An intranuclear focus at which aggregated proteins have been sequestered.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Nuclear pore nuclear basket GO:0044615
A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Nucleoplasmic side of nuclear pore GO:1990875
The side of the nuclear pore complex (NPC) that faces the nucleoplasm.
|
3 | E9Q3G8 (/ISO) Q80UN3 (/ISO) Q80WR0 (/ISO) |
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
|
2 | P49790 (/IDA) P49791 (/IDA) |
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
2 | P49790 (/IDA) P49791 (/IDA) |
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
|
2 | P49790 (/IDA) P49791 (/IDA) |
Nuclear inclusion body GO:0042405
An intranuclear focus at which aggregated proteins have been sequestered.
|
2 | P49790 (/IDA) P49791 (/IDA) |
Nuclear pore nuclear basket GO:0044615
A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component.
|
2 | P49790 (/IDA) P49791 (/IDA) |
Annulate lamellae GO:0005642
Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER.
|
1 | P49791 (/IDA) |
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
|
1 | P49791 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P49790 (/TAS) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | P49790 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P49790 (/IDA) |
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
1 | P49791 (/ISS) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | P49791 (/IDA) |
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
|
1 | P49791 (/ISS) |
Nucleoplasmic side of nuclear pore GO:1990875
The side of the nuclear pore complex (NPC) that faces the nucleoplasm.
|
1 | P49791 (/IDA) |