The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
CRIB domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Neural Wiskott-Aldrich syndrome protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 O00401 (/IPI) O00401 (/IPI) O00401 (/IPI) O08816 (/IPI) Q91YD9 (/IPI) Q91YD9 (/IPI) Q95107 (/IPI) Q95107 (/IPI)
GTPase regulator activity GO:0030695
Modulates the rate of GTP hydrolysis by a GTPase.
3 O00401 (/TAS) O00401 (/TAS) O00401 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 O08816 (/IPI) Q95107 (/IPI) Q95107 (/IPI)
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
1 O08816 (/IPI)

There are 45 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
6 O00401 (/ISS) O00401 (/ISS) O00401 (/ISS) O08816 (/ISS) Q95107 (/ISS) Q95107 (/ISS)
Vesicle budding from membrane GO:0006900
The evagination of a membrane, resulting in formation of a vesicle.
5 O00401 (/ISS) O00401 (/ISS) O00401 (/ISS) Q91YD9 (/ISS) Q91YD9 (/ISS)
Vesicle organization GO:0016050
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
5 O00401 (/ISS) O00401 (/ISS) O00401 (/ISS) Q91YD9 (/ISS) Q91YD9 (/ISS)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
5 O08816 (/ISS) Q91YD9 (/ISS) Q91YD9 (/ISS) Q95107 (/ISS) Q95107 (/ISS)
Vesicle transport along actin filament GO:0030050
Movement of a vesicle along an actin filament, mediated by motor proteins.
5 O00401 (/ISS) O00401 (/ISS) O00401 (/ISS) Q91YD9 (/ISS) Q91YD9 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
5 O08816 (/ISS) Q91YD9 (/ISS) Q91YD9 (/ISS) Q95107 (/ISS) Q95107 (/ISS)
Positive regulation of filopodium assembly GO:0051491
Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
5 O00401 (/ISS) O00401 (/ISS) O00401 (/ISS) Q91YD9 (/ISS) Q91YD9 (/ISS)
Positive regulation of clathrin-dependent endocytosis GO:2000370
Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis.
5 O00401 (/ISS) O00401 (/ISS) O00401 (/ISS) Q91YD9 (/ISS) Q91YD9 (/ISS)
Thrombocyte differentiation GO:0002574
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
3 A0A2R8QKQ7 (/IMP) A2RUY4 (/IMP) F1QNY1 (/IMP)
Actin polymerization or depolymerization GO:0008154
Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
3 O00401 (/TAS) O00401 (/TAS) O00401 (/TAS)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
3 O00401 (/IDA) O00401 (/IDA) O00401 (/IDA)
Macrophage differentiation GO:0030225
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
3 A0A2R8QKQ7 (/IMP) A2RUY4 (/IMP) F1QNY1 (/IMP)
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
3 O00401 (/TAS) O00401 (/TAS) O00401 (/TAS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 O00401 (/IDA) O00401 (/IDA) O00401 (/IDA)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
3 O00401 (/TAS) O00401 (/TAS) O00401 (/TAS)
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
3 O00401 (/TAS) O00401 (/TAS) O00401 (/TAS)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
3 O00401 (/TAS) O00401 (/TAS) O00401 (/TAS)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
3 O00401 (/TAS) O00401 (/TAS) O00401 (/TAS)
Negative regulation of membrane tubulation GO:1903526
Any process that stops, prevents or reduces the frequency, rate or extent of membrane tubulation.
3 O00401 (/IDA) O00401 (/IDA) O00401 (/IDA)
Negative regulation of lymphocyte migration GO:2000402
Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration.
3 O00401 (/IMP) O00401 (/IMP) O00401 (/IMP)
Vesicle budding from membrane GO:0006900
The evagination of a membrane, resulting in formation of a vesicle.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
2 Q91YD9 (/IMP) Q91YD9 (/IMP)
Membrane invagination GO:0010324
The infolding of a membrane.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Vesicle organization GO:0016050
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 Q91YD9 (/IMP) Q91YD9 (/IMP)
Vesicle transport along actin filament GO:0030050
Movement of a vesicle along an actin filament, mediated by motor proteins.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
2 Q91YD9 (/IMP) Q91YD9 (/IMP)
Cellular protein-containing complex localization GO:0034629
A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell.
2 Q91YD9 (/IMP) Q91YD9 (/IMP)
Actin nucleation GO:0045010
The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
2 Q91YD9 (/TAS) Q91YD9 (/TAS)
Positive regulation of filopodium assembly GO:0051491
Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Spindle localization GO:0051653
Any process in which is the spindle is transported to, and/or maintained in, a specific location.
2 Q91YD9 (/IMP) Q91YD9 (/IMP)
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
2 Q91YD9 (/IMP) Q91YD9 (/IMP)
Plasma membrane tubulation GO:0097320
A membrane tubulation process occurring in a plasma membrane.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Postsynaptic actin cytoskeleton organization GO:0098974
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Positive regulation of clathrin-dependent endocytosis GO:2000370
Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Vesicle budding from membrane GO:0006900
The evagination of a membrane, resulting in formation of a vesicle.
1 O08816 (/IDA)
Membrane invagination GO:0010324
The infolding of a membrane.
1 O08816 (/IDA)
Vesicle organization GO:0016050
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
1 O08816 (/IDA)
Vesicle transport along actin filament GO:0030050
Movement of a vesicle along an actin filament, mediated by motor proteins.
1 O08816 (/IDA)
Positive regulation of filopodium assembly GO:0051491
Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
1 O08816 (/IDA)
Plasma membrane tubulation GO:0097320
A membrane tubulation process occurring in a plasma membrane.
1 O08816 (/IDA)
Postsynaptic actin cytoskeleton organization GO:0098974
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
1 O08816 (/EXP)
Postsynaptic actin cytoskeleton organization GO:0098974
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
1 O08816 (/IDA)
Postsynaptic actin cytoskeleton organization GO:0098974
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
1 O08816 (/IMP)
Positive regulation of clathrin-dependent endocytosis GO:2000370
Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis.
1 O08816 (/IDA)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 O00401 (/TAS) O00401 (/TAS) O00401 (/TAS) O08816 (/TAS) Q91YD9 (/TAS) Q91YD9 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 O08816 (/ISS) Q91YD9 (/ISS) Q91YD9 (/ISS) Q95107 (/ISS) Q95107 (/ISS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
5 O00401 (/ISS) O00401 (/ISS) O00401 (/ISS) Q91YD9 (/ISS) Q91YD9 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O00401 (/IDA) O00401 (/IDA) O00401 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O00401 (/IDA) O00401 (/IDA) O00401 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O00401 (/TAS) O00401 (/TAS) O00401 (/TAS)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
3 O00401 (/TAS) O00401 (/TAS) O00401 (/TAS)
Endocytic vesicle membrane GO:0030666
The lipid bilayer surrounding an endocytic vesicle.
3 O00401 (/TAS) O00401 (/TAS) O00401 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 O00401 (/HDA) O00401 (/HDA) O00401 (/HDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q91YD9 (/IC) Q91YD9 (/IC)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
2 Q91YD9 (/IDA) Q91YD9 (/IDA)
Actin cap GO:0030478
Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae.
2 Q91YD9 (/IDA) Q91YD9 (/IDA)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 Q91YD9 (/ISO) Q91YD9 (/ISO)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 O08816 (/IDA)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
1 O08816 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 O08816 (/IDA)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
1 O08816 (/IDA)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
1 O08816 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 O08816 (/EXP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 O08816 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 O08816 (/IMP)
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