View in Gene3D

CATH Superfamily 3.90.79.10

Nucleoside Triphosphate Pyrophosphohydrolase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleoside Triphosphate Pyrophosphohydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 80: 8-oxo-dGDP phosphatase NUDT18

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
8-oxo-dGDP phosphatase. [EC: 3.6.1.58]
8-oxo-dGDP + H(2)O = 8-oxo-dGMP + phosphate.
  • The enzyme catalyzes the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage.
  • The preferred in vivo substrate is not known.
  • The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55).
  • Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolyzed with broad specificity.
  • The bifunctional enzyme NUDT5 also hydrolyzes ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13).
  • The human enzyme NUDT18 also hydrolyzes 8-oxo-dADP and 2-hydroxy- dADP, the latter at a slower rate.
 8 B0BNL9 B0BNL9 H2QVU3 Q3U2V3 Q568Q0 Q641Y7 Q641Y7 Q6ZVK8
CATH-Gene3D is a Global Biodata Core Resource Learn more...