The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleoside Triphosphate Pyrophosphohydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 55: U8 snoRNA-decapping enzyme

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 44 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DITP diphosphatase activity GO:0035870
Catalysis of the reaction: dITP + H2O = dIMP + diphosphate.
5 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q96DE0 (/ISS) Q96DE0 (/ISS) Q96DE0 (/ISS)
Nucleotide phosphatase activity, acting on free nucleotides GO:0098519
Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate.
4 Q6P3D0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
Metalloexopeptidase activity GO:0008235
Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
Metalloexopeptidase activity GO:0008235
Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
SnoRNA binding GO:0030515
Interacting selectively and non-covalently with small nucleolar RNA.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
SnoRNA binding GO:0030515
Interacting selectively and non-covalently with small nucleolar RNA.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
Chloride ion binding GO:0031404
Interacting selectively and non-covalently with chloride ions (Cl-).
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 Q96DE0 (/IPI) Q96DE0 (/IPI) Q96DE0 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
M7G(5')pppN diphosphatase activity GO:0050072
Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
M7G(5')pppN diphosphatase activity GO:0050072
Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
Cobalt ion binding GO:0050897
Interacting selectively and non-covalently with a cobalt (Co) ion.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
Cobalt ion binding GO:0050897
Interacting selectively and non-covalently with a cobalt (Co) ion.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
XTP binding GO:1901640
Interacting selectively and non-covalently with XTP.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
XTP binding GO:1901640
Interacting selectively and non-covalently with XTP.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
ITP binding GO:1901641
Interacting selectively and non-covalently with ITP.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
ITP binding GO:1901641
Interacting selectively and non-covalently with ITP.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
Phosphodiesterase decapping endonuclease activity GO:1990174
Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
Nucleotide phosphatase activity, acting on free nucleotides GO:0098519
Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate.
2 A1A4Q9 (/ISS) Q2V8X7 (/ISS)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 Q6P3D0 (/ISO)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q6P3D0 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 Q6P3D0 (/ISO)
Metalloexopeptidase activity GO:0008235
Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 Q6P3D0 (/ISO)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 Q6P3D0 (/ISO)
SnoRNA binding GO:0030515
Interacting selectively and non-covalently with small nucleolar RNA.
1 Q6P3D0 (/ISO)
Chloride ion binding GO:0031404
Interacting selectively and non-covalently with chloride ions (Cl-).
1 Q6P3D0 (/ISO)
DITP diphosphatase activity GO:0035870
Catalysis of the reaction: dITP + H2O = dIMP + diphosphate.
1 Q6P3D0 (/IMP)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q6P3D0 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q6P3D0 (/ISO)
M7G(5')pppN diphosphatase activity GO:0050072
Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide.
1 Q6P3D0 (/ISO)
Cobalt ion binding GO:0050897
Interacting selectively and non-covalently with a cobalt (Co) ion.
1 Q6P3D0 (/ISO)
Nucleotide phosphatase activity, acting on free nucleotides GO:0098519
Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate.
1 Q6P3D0 (/ISO)
XTP binding GO:1901640
Interacting selectively and non-covalently with XTP.
1 Q6P3D0 (/ISO)
ITP binding GO:1901641
Interacting selectively and non-covalently with ITP.
1 Q6P3D0 (/ISO)
Phosphodiesterase decapping endonuclease activity GO:1990174
Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA.
1 Q6P3D0 (/ISO)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of rRNA processing GO:2000233
Any process that stops, prevents, or reduces the frequency, rate or extent of rRNA processing.
6 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS) Q96DE0 (/ISS) Q96DE0 (/ISS) Q96DE0 (/ISS)
DITP catabolic process GO:0035863
The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position.
5 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q96DE0 (/ISS) Q96DE0 (/ISS) Q96DE0 (/ISS)
Adenosine to inosine editing GO:0006382
The conversion of an adenosine residue to inosine in an RNA molecule by deamination.
3 Q96DE0 (/IMP) Q96DE0 (/IMP) Q96DE0 (/IMP)
Adenosine to inosine editing GO:0006382
The conversion of an adenosine residue to inosine in an RNA molecule by deamination.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
3 Q96DE0 (/IMP) Q96DE0 (/IMP) Q96DE0 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
SnoRNA catabolic process GO:0016077
The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
SnoRNA catabolic process GO:0016077
The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
Nucleobase-containing small molecule catabolic process GO:0034656
The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
3 Q96DE0 (/TAS) Q96DE0 (/TAS) Q96DE0 (/TAS)
IDP catabolic process GO:0046709
The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
IDP catabolic process GO:0046709
The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
Positive regulation of cell cycle process GO:0090068
Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
3 Q96DE0 (/IMP) Q96DE0 (/IMP) Q96DE0 (/IMP)
Positive regulation of cell cycle process GO:0090068
Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502
The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
XDP catabolic process GO:1901639
The chemical reactions and pathways resulting in the breakdown of XDP.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
XDP catabolic process GO:1901639
The chemical reactions and pathways resulting in the breakdown of XDP.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
Positive regulation of double-strand break repair GO:2000781
Any process that activates or increases the frequency, rate or extent of double-strand break repair.
3 Q96DE0 (/IMP) Q96DE0 (/IMP) Q96DE0 (/IMP)
Positive regulation of double-strand break repair GO:2000781
Any process that activates or increases the frequency, rate or extent of double-strand break repair.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
2 A1A4Q9 (/ISS) Q2V8X7 (/ISS)
Adenosine to inosine editing GO:0006382
The conversion of an adenosine residue to inosine in an RNA molecule by deamination.
1 Q6P3D0 (/ISO)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
1 Q6P3D0 (/IMP)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
1 Q6P3D0 (/ISO)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q6P3D0 (/ISO)
SnoRNA catabolic process GO:0016077
The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins.
1 Q6P3D0 (/ISO)
DITP catabolic process GO:0035863
The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position.
1 Q6P3D0 (/IGI)
IDP catabolic process GO:0046709
The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate.
1 Q6P3D0 (/ISO)
Chromosome organization GO:0051276
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
1 Q6P3D0 (/IGI)
Positive regulation of cell cycle process GO:0090068
Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
1 Q6P3D0 (/ISO)
RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502
The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides.
1 Q6P3D0 (/ISO)
XDP catabolic process GO:1901639
The chemical reactions and pathways resulting in the breakdown of XDP.
1 Q6P3D0 (/ISO)
Positive regulation of double-strand break repair GO:2000781
Any process that activates or increases the frequency, rate or extent of double-strand break repair.
1 Q6P3D0 (/ISO)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q96DE0 (/HDA) Q96DE0 (/HDA) Q96DE0 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 Q96DE0 (/TAS) Q96DE0 (/TAS) Q96DE0 (/TAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q96DE0 (/IDA) Q96DE0 (/IDA) Q96DE0 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 A1A4Q9 (/ISS) Q2V8X7 (/ISS) Q6P3D0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6P3D0 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q6P3D0 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q6P3D0 (/ISO)