The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleoside Triphosphate Pyrophosphohydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 21: ADP-ribose pyrophosphatase, mitochondrial isoform ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ADP-sugar diphosphatase activity GO:0019144
Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate.
4 Q8NG26 (/NAS) Q96KB3 (/NAS) Q9BW91 (/NAS) Q9BW91 (/NAS)
Calcium activated cation channel activity GO:0005227
Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient.
2 Q8NG26 (/NAS) Q96KB3 (/NAS)
ADP-ribose diphosphatase activity GO:0047631
Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.
2 Q9BW91 (/EXP) Q9BW91 (/EXP)
Ligand-gated sodium channel activity GO:0015280
Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
1 A7T1N0 (/IDA)
Adenosine-diphosphatase activity GO:0043262
Catalysis of the reaction: ADP + H2O = AMP + phosphate.
1 Q8BVU5 (/IDA)
ADP-ribose diphosphatase activity GO:0047631
Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.
1 A7T1N0 (/IMP)
ADP-ribose diphosphatase activity GO:0047631
Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.
1 Q8BVU5 (/ISO)
Ligand-gated calcium channel activity GO:0099604
Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
1 A7T1N0 (/IDA)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cation transport GO:0006812
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q8NG26 (/NAS) Q96KB3 (/NAS)
Nucleobase-containing small molecule catabolic process GO:0034656
The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
2 Q9BW91 (/TAS) Q9BW91 (/TAS)
Sodium ion transmembrane transport GO:0035725
A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 A7T1N0 (/IDA)
ADP catabolic process GO:0046032
The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate.
1 Q8BVU5 (/IDA)
IDP catabolic process GO:0046709
The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate.
1 Q8BVU5 (/IDA)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 A7T1N0 (/IDA)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q9BW91 (/TAS) Q9BW91 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q9BW91 (/HDA) Q9BW91 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8BVU5 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8BVU5 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 A7T1N0 (/IDA)
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