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CATH Superfamily 3.90.700.10

Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: NADH-dependent fumarate reductase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Fumarate reductase (NADH). [EC: 1.3.1.6]
Succinate + NAD(+) = fumarate + NADH.
    		 86 A6ZQ10 A6ZQ10 A6ZQ10 A6ZQ10 A6ZQ10 A6ZQ10 B3LQE0 B3LQE0 B3LQE0 B3LQE0
    (76 more...)
    3-oxo-5-alpha-steroid 4-dehydrogenase (acceptor). [EC: 1.3.99.5]
    A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.
    • This bacterial enzyme, characterized from Comamonas testosteroni, is involved in androsterone degradation.
    • Cf. EC 1.3.1.22.
    		 1 Q59327
    Urocanate reductase. [EC: 1.3.99.33]
    Dihydrourocanate + acceptor = urocanate + reduced acceptor.
    • The enzyme functions as part of an anaerobic electron transfer chain that utilizes urocanate as the terminal electron acceptor.
    • The activity has been demonstrated with the artificial donor reduced methyl viologen.
    		 1 Q8CVD0
    Fumarate reductase (quinol). [EC: 1.3.5.4]
    Succinate + a quinone = fumarate + a quinol.
    • The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain.
    • The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.
    		 1 P83223
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