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CATH Superfamily 3.90.550.50

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: Hexosyltransferase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase. [EC: 2.4.1.149]
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl- beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D- galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.
  • Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on glycoproteins, glycolipids, and oligosaccharides.
  • Formerly EC 2.4.1.163.
 7 A0A024RBT1 A0A024RBT1 Q1RLK6 Q5JCS9 Q9C0J1 Q9C0J1 Q9Y2A9
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N- acetylglucosaminyltransferase. [EC: 2.4.1.147]
UDP-N-acetyl-alpha-D-glucosamine + O(3)-(N-acetyl-alpha-D- galactosaminyl)-L-threonyl/L-seryl-[protein] = UDP + O(3)-(N-acetyl-beta- D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl)-L- threonyl/L-seryl-[protein].
  • The product of the enzyme is known as core 3, one of the eight core structures of mucin-type O-glycans.
  • O-linked glycans are polysaccharides or oligosaccharides that are linked to a protein via the oxygen atom in the side chain of an L-serine or L-threonine residue.
 5 A8K9Q8 A8K9Q8 Q3USF0 Q6ZMB0 Q6ZMB0
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N- acetylglucosaminyltransferase. [EC: 2.4.1.146]
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(beta-D-galactosyl-(1->3)- (N-acetyl-beta-D-glucosaminyl-(1->6))-N-acetyl-alpha-D-galactosaminyl)-L- seryl/threonyl-[protein] = UDP + 3-O-(N-acetyl-beta-D-glucosaminyl- (1->3)-beta-D-galactosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->6))-N- acetyl-alpha-D-galactosaminyl)-L-seryl/threonyl-[protein].
  • The enzyme catalyzes the addition of N-acetyl-alpha-D-glucosamine to the core 2 structure of O-glycans.
 2 Q5JCS9 Q9Y2A9
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