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CATH Superfamily 3.90.550.50

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Hexosyltransferase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase. [EC: 2.4.1.226]
(1) UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine. (2) UDP-alpha-D-glucuronate + [protein]-3-O-((beta-D-GalNAc-(1->4)-beta- D-GlcA-(1->3))(n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal- (1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3- O-(beta-D-GlcA-(1->3)-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3))(n)-beta- D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)- beta-D-Xyl)-L-serine.
  • Involved in the biosynthesis of chondroitin and dermatan sulfate.
  • The human chondroitin synthetase is a bifunctional glycosyltransferase, which also has the EC 2.4.1.175 activity required for the synthesis of the chondroitin sulfate disaccharide repeats.
  • Similar chondroitin synthase 'copolymerases' can be found in Pasteurella multocida and Escherichia coli.
  • There is also another human protein with apparently only the 3-beta- glucuronosyltransferase activity.
 14 A0A0K3ATP9 A0A0K3ATP9 A0A2I2YWR5 A0A2I2YWR5 Q5DTK1 Q6IQX7 Q6ZQ11 Q70JA7 Q7Z1Z1 Q7Z1Z1
(4 more...)
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase. [EC: 2.4.1.175]
(1) UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA- (1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D- Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GalNAc- (1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D- Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine. (2) UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA- (1->3)-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3))(n)-beta-D-GalNAc-(1->4)- beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L- serine = UDP + [protein]-3-O-((beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3))(n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)- beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine.
  • Involved in the biosynthesis of chondroitin sulfate.
  • The human form of this enzyme is a bifunctional glycosyltransferase, which also has the EC 2.4.1.226 activity required for the synthesis of the chondroitin sulfate disaccharide repeats.
  • Similar chondroitin synthase 'copolymerases' can be found in Pasteurella multocida and Escherichia coli.
 10 A0A0K3ATP9 A0A0K3ATP9 Q5DTK1 Q6IQX7 Q6ZQ11 Q70JA7 Q7Z1Z1 Q7Z1Z1 Q86X52 Q8IZ52
Glucuronylgalactosylproteoglycan 4-beta-N- acetylgalactosaminyltransferase. [EC: 2.4.1.174]
UDP-N-acetyl-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D- Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3- O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal- (1->4)-beta-D-Xyl)-L-serine.
  • Involved in the biosynthesis of chondroitin sulfate.
  • Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core.
 4 A0A0K3ATP9 A0A0K3ATP9 Q7Z1Z1 Q7Z1Z1
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