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CATH Superfamily 3.90.550.50

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Hexosyltransferase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase. [EC: 2.4.1.86]
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-R = UDP + beta-D- galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R.
  • The enzyme transfers galactose from UDP-alpha-D-galactose to the 3-position of substrates with a non-reducing terminal N-acetyl-beta- D-glucosamine (beta-GlcNAc) residue.
  • It can act on both glycolipids and glycoproteins, generating a structure known as the type 1 histo-blood group antigen precursor.
 1222 A0A096MMX5 A0A096MMX5 A0A096MMX5 A0A096MMX5 A0A096MMX5 A0A096MMX5 A0A096MMX5 A0A096MMX5 A0A096NBK0 A0A096NBK0
(1212 more...)
Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase. [EC: 2.4.1.79]
UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta- D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl- (1->4)-beta-D-glucosyl-(1<->1)-ceramide.
  • Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity.
  • UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity.
  • Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates.
 11 A0A481AY33 A0A481AY33 O75752 Q5RAL7 Q6AY39 Q793U7 Q793U7 Q864U6 Q864U6 Q920V1
(1 more...)
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