The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 50: hyaluronan synthase 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hyaluronan synthase activity GO:0050501
Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine =
93 B1WAU6 (/ISS) D2HYK7 (/ISS) D2HYK7 (/ISS) D2HYK7 (/ISS) D2HYK7 (/ISS) F1S290 (/ISS) F6UTD9 (/ISS) F6UTD9 (/ISS) F6UTD9 (/ISS) F6UTD9 (/ISS)
(83 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
16 Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI)
(6 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
16 Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI) Q92819 (/IPI)
(6 more)
Hyaluronan synthase activity GO:0050501
Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine =
16 Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP)
(6 more)
Hyaluronan synthase activity GO:0050501
Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine =
2 O35776 (/IDA) P70312 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P70312 (/ISO)
Hyaluronan synthase activity GO:0050501
Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine =
1 P70312 (/ISO)

There are 63 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hyaluronan biosynthetic process GO:0030213
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
93 B1WAU6 (/ISS) D2HYK7 (/ISS) D2HYK7 (/ISS) D2HYK7 (/ISS) D2HYK7 (/ISS) F1S290 (/ISS) F6UTD9 (/ISS) F6UTD9 (/ISS) F6UTD9 (/ISS) F6UTD9 (/ISS)
(83 more)
Positive regulation of urine volume GO:0035810
Any process that increases the amount of urine excreted from the body over a unit of time.
93 B1WAU6 (/ISS) D2HYK7 (/ISS) D2HYK7 (/ISS) D2HYK7 (/ISS) D2HYK7 (/ISS) F1S290 (/ISS) F6UTD9 (/ISS) F6UTD9 (/ISS) F6UTD9 (/ISS) F6UTD9 (/ISS)
(83 more)
Renal water absorption GO:0070295
A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.
93 B1WAU6 (/ISS) D2HYK7 (/ISS) D2HYK7 (/ISS) D2HYK7 (/ISS) D2HYK7 (/ISS) F1S290 (/ISS) F6UTD9 (/ISS) F6UTD9 (/ISS) F6UTD9 (/ISS) F6UTD9 (/ISS)
(83 more)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
22 G5AY81 (/ISS) O35776 (/ISS) O57424 (/ISS) O57427 (/ISS) O57427 (/ISS) O97711 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS)
(12 more)
Atrioventricular canal development GO:0036302
The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle.
22 G5AY81 (/ISS) O35776 (/ISS) O57424 (/ISS) O57427 (/ISS) O57427 (/ISS) O97711 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS)
(12 more)
Extracellular polysaccharide biosynthetic process GO:0045226
The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures.
22 G5AY81 (/ISS) O35776 (/ISS) O57424 (/ISS) O57427 (/ISS) O57427 (/ISS) O97711 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS)
(12 more)
Extracellular matrix assembly GO:0085029
The aggregation, arrangement and bonding together of the extracellular matrix.
22 G5AY81 (/ISS) O35776 (/ISS) O57424 (/ISS) O57427 (/ISS) O57427 (/ISS) O97711 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS)
(12 more)
Endocardial cushion to mesenchymal transition GO:0090500
A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
22 G5AY81 (/ISS) O35776 (/ISS) O57424 (/ISS) O57427 (/ISS) O57427 (/ISS) O97711 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS)
(12 more)
Hyaluronan biosynthetic process GO:0030213
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
17 P70312 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP)
(7 more)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
16 Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS) Q92819 (/ISS)
(6 more)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
16 Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP)
(6 more)
Hyaluronan biosynthetic process GO:0030213
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
16 Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA)
(6 more)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
16 Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP)
(6 more)
Cellular response to platelet-derived growth factor stimulus GO:0036120
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
16 Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA)
(6 more)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
16 Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP)
(6 more)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
16 Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP)
(6 more)
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
16 Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP) Q92819 (/IEP)
(6 more)
Positive regulation of monocyte aggregation GO:1900625
Any process that activates or increases the frequency, rate or extent of monocyte aggregation.
16 Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP) Q92819 (/IMP)
(6 more)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
1 Q9DG41 (/IGI)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
1 P70312 (/IMP)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 Q9DG41 (/IMP)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 O35776 (/IEP)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
1 Q9DG41 (/IGI)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
1 Q9DG41 (/IMP)
Heart jogging GO:0003146
The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis.
1 Q9DG41 (/IGI)
Atrioventricular valve development GO:0003171
The progression of the atrioventricular valve over time, from its formation to the mature structure.
1 Q9DG41 (/IGI)
Atrioventricular valve morphogenesis GO:0003181
The process in which the structure of the atrioventricular valve is generated and organized.
1 Q9DG41 (/IMP)
Mesodermal cell migration GO:0008078
The orderly movement of mesodermal cells from one site to another.
1 Q9DG41 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P70312 (/ISO)
Positive regulation of keratinocyte proliferation GO:0010838
Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
1 O35776 (/IMP)
Positive regulation of keratinocyte proliferation GO:0010838
Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
1 P70312 (/ISO)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
1 O35776 (/IMP)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
1 P70312 (/ISO)
Cell migration in hindbrain GO:0021535
The orderly movement of a cell that will reside in the hindbrain.
1 Q9DG41 (/IMP)
Hyaluronan metabolic process GO:0030212
The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
1 P70312 (/IMP)
Hyaluronan biosynthetic process GO:0030213
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
1 O35776 (/IEP)
Hyaluronan biosynthetic process GO:0030213
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
1 P70312 (/ISO)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 P70312 (/ISO)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
1 Q9DG41 (/IMP)
Embryonic heart tube development GO:0035050
The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
1 Q9DG41 (/IMP)
Positive regulation of urine volume GO:0035810
Any process that increases the amount of urine excreted from the body over a unit of time.
1 O35776 (/IEP)
Cellular response to platelet-derived growth factor stimulus GO:0036120
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
1 P70312 (/ISO)
Atrioventricular canal development GO:0036302
The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle.
1 Q9DG41 (/IGI)
Atrioventricular canal development GO:0036302
The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle.
1 P70312 (/IMP)
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
1 Q9DG41 (/IMP)
Estrous cycle GO:0044849
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
1 O35776 (/IEP)
Extracellular polysaccharide biosynthetic process GO:0045226
The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures.
1 P70312 (/IDA)
Positive regulation of keratinocyte migration GO:0051549
Any process that activates or increases the frequency, rate or extent of keratinocyte migration.
1 O35776 (/IDA)
Positive regulation of keratinocyte migration GO:0051549
Any process that activates or increases the frequency, rate or extent of keratinocyte migration.
1 P70312 (/ISO)
Dorsal convergence GO:0060030
The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement.
1 Q9DG41 (/IGI)
Bone morphogenesis GO:0060349
The process in which bones are generated and organized.
1 P70312 (/IMP)
Renal water absorption GO:0070295
A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.
1 O35776 (/IEP)
Extracellular matrix assembly GO:0085029
The aggregation, arrangement and bonding together of the extracellular matrix.
1 P70312 (/IDA)
Endocardial cushion to mesenchymal transition GO:0090500
A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 P70312 (/IMP)
Positive regulation of substrate adhesion-dependent cell spreading GO:1900026
Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.
1 O35776 (/IMP)
Positive regulation of substrate adhesion-dependent cell spreading GO:1900026
Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.
1 P70312 (/ISO)
Positive regulation of hyaluronan biosynthetic process GO:1900127
Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process.
1 O35776 (/IDA)
Positive regulation of hyaluronan biosynthetic process GO:1900127
Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process.
1 O35776 (/IMP)
Positive regulation of hyaluronan biosynthetic process GO:1900127
Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process.
1 P70312 (/ISO)
Positive regulation of monocyte aggregation GO:1900625
Any process that activates or increases the frequency, rate or extent of monocyte aggregation.
1 P70312 (/ISO)
Regulation of extracellular matrix assembly GO:1901201
Any process that modulates the frequency, rate or extent of extracellular matrix assembly.
1 O35776 (/IMP)
Regulation of extracellular matrix assembly GO:1901201
Any process that modulates the frequency, rate or extent of extracellular matrix assembly.
1 P70312 (/ISO)
Regulation of BMP signaling pathway involved in heart jogging GO:2000223
Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in heart jogging.
1 Q9DG41 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
16 Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA) Q92819 (/IDA)
(6 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P70312 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P70312 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9DG41 (/NAS)
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
1 P70312 (/IDA)
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