The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"RTP801-like
".
FunFam 1: DNA damage-inducible transcript 4 protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
3 | Q9D3F7 (/IDA) Q9D3F7 (/IDA) Q9D3F7 (/IDA) |
There are 45 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
7 | Q08E62 (/ISS) Q08E62 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9NX09 (/ISS) Q9NX09 (/ISS) |
|
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
7 | Q08E62 (/ISS) Q08E62 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9NX09 (/ISS) Q9NX09 (/ISS) |
|
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
7 | Q08E62 (/ISS) Q08E62 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9NX09 (/ISS) Q9NX09 (/ISS) |
|
Negative regulation of peptidyl-threonine phosphorylation GO:0010801
Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
7 | Q08E62 (/ISS) Q08E62 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9NX09 (/ISS) Q9NX09 (/ISS) |
|
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
7 | Q08E62 (/ISS) Q08E62 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9NX09 (/ISS) Q9NX09 (/ISS) |
|
Negative regulation of peptidyl-serine phosphorylation GO:0033137
Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
7 | Q08E62 (/ISS) Q08E62 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9NX09 (/ISS) Q9NX09 (/ISS) |
|
Neurotrophin TRK receptor signaling pathway GO:0048011
A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
7 | Q08E62 (/ISS) Q08E62 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9NX09 (/ISS) Q9NX09 (/ISS) |
|
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
|
7 | Q08E62 (/ISS) Q08E62 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9NX09 (/ISS) Q9NX09 (/ISS) |
|
Negative regulation of intracellular signal transduction GO:1902532
Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.
|
7 | Q08E62 (/ISS) Q08E62 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9D3F7 (/ISS) Q9NX09 (/ISS) Q9NX09 (/ISS) |
|
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
|
6 | Q8VHZ9 (/IMP) Q9D3F7 (/IMP) Q9D3F7 (/IMP) Q9D3F7 (/IMP) Q9NX09 (/IMP) Q9NX09 (/IMP) |
|
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
5 | Q08E62 (/ISS) Q08E62 (/ISS) Q8VHZ9 (/ISS) Q9NX09 (/ISS) Q9NX09 (/ISS) |
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
3 | Q8VHZ9 (/IDA) Q9NX09 (/IDA) Q9NX09 (/IDA) |
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
3 | Q9D3F7 (/IMP) Q9D3F7 (/IMP) Q9D3F7 (/IMP) |
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Negative regulation of peptidyl-threonine phosphorylation GO:0010801
Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Protein-containing complex disassembly GO:0032984
The disaggregation of a protein-containing macromolecular complex into its constituent components.
|
3 | Q9D3F7 (/IMP) Q9D3F7 (/IMP) Q9D3F7 (/IMP) |
|
Negative regulation of peptidyl-serine phosphorylation GO:0033137
Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
3 | Q9D3F7 (/IMP) Q9D3F7 (/IMP) Q9D3F7 (/IMP) |
|
Negative regulation of glycolytic process GO:0045820
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
|
3 | Q9D3F7 (/IMP) Q9D3F7 (/IMP) Q9D3F7 (/IMP) |
|
Neurotrophin TRK receptor signaling pathway GO:0048011
A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Cellular response to dexamethasone stimulus GO:0071549
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
|
3 | Q9D3F7 (/IDA) Q9D3F7 (/IDA) Q9D3F7 (/IDA) |
|
Reactive oxygen species metabolic process GO:0072593
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
|
3 | Q9D3F7 (/IMP) Q9D3F7 (/IMP) Q9D3F7 (/IMP) |
|
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Negative regulation of intracellular signal transduction GO:1902532
Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
2 | Q08E62 (/ISS) Q08E62 (/ISS) |
|
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
2 | Q7T346 (/IMP) Q7T346 (/IMP) |
|
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
|
2 | Q08E62 (/ISS) Q08E62 (/ISS) |
|
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
2 | Q9NX09 (/IDA) Q9NX09 (/IDA) |
|
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
1 | Q8VHZ9 (/IMP) |
|
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
1 | Q8VHZ9 (/IDA) |
|
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
1 | Q8VHZ9 (/IMP) |
|
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
1 | Q8VHZ9 (/IMP) |
|
Negative regulation of peptidyl-threonine phosphorylation GO:0010801
Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
1 | Q8VHZ9 (/IMP) |
|
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
1 | Q8VHZ9 (/IMP) |
|
Negative regulation of peptidyl-serine phosphorylation GO:0033137
Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
1 | Q8VHZ9 (/IMP) |
|
Neurotrophin TRK receptor signaling pathway GO:0048011
A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q8VHZ9 (/IMP) |
|
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
|
1 | Q8VHZ9 (/IMP) |
|
Negative regulation of intracellular signal transduction GO:1902532
Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.
|
1 | Q8VHZ9 (/IMP) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
11 |
Q08E62 (/ISS)
Q08E62 (/ISS)
Q6P4J6 (/ISS)
Q7SYV9 (/ISS)
Q7SYV9 (/ISS)
Q7T346 (/ISS)
Q7T346 (/ISS)
Q8VHZ9 (/ISS)
Q9D3F7 (/ISS)
Q9D3F7 (/ISS)
(1 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | A0A024QZQ6 (/IDA) A0A024QZQ6 (/IDA) Q9NX09 (/IDA) Q9NX09 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | Q9D3F7 (/IDA) Q9D3F7 (/IDA) Q9D3F7 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q9D3F7 (/ISO) Q9D3F7 (/ISO) Q9D3F7 (/ISO) |
|
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
|
2 | Q9NX09 (/IDA) Q9NX09 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q9NX09 (/IDA) Q9NX09 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9NX09 (/TAS) Q9NX09 (/TAS) |