The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
2-enoyl-CoA Hydratase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: Fatty acid oxidation complex subunit alpha

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Delta(3)-Delta(2)-enoyl-CoA isomerase. [EC: 5.3.3.8]
(1) A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA. (2) A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.
  • The enzyme participates in the beta-oxidation of fatty acids with double bonds at an odd position.
  • Processing of these substrates via the beta-oxidation system results in intermediates with a cis- or trans-double bond at position C(3), which cannot be processed further by the regular enzymes of the beta- oxidation system.
  • This enzyme isomerizes the bond to a trans bond at position C(2), which can be processed further.
  • The reaction rate is ten times higher for the (3Z) isomers than for (3E) isomers.
  • The enzyme can also catalyze the isomerization of 3-acetylenic fatty acyl thioesters to 2,3-dienoyl fatty acyl thioesters.
1564 A0A029HEK6 A0A029HEK6 A0A029HEK6 A0A029IHZ1 A0A029IHZ1 A0A029IHZ1 A0A069QB72 A0A069QB72 A0A069QB72 A0A069QB72
(1554 more...)
3-hydroxybutyryl-CoA epimerase. [EC: 5.1.2.3]
(S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.
    1564 A0A029HEK6 A0A029HEK6 A0A029HEK6 A0A029IHZ1 A0A029IHZ1 A0A029IHZ1 A0A069QB72 A0A069QB72 A0A069QB72 A0A069QB72
    (1554 more...)
    3-hydroxyacyl-CoA dehydrogenase. [EC: 1.1.1.35]
    (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
    • Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.
    • Some enzymes act, more slowly, with NADP(+).
    • Broad specificity to acyl chain-length (cf. EC 1.1.1.211).
    1564 A0A029HEK6 A0A029HEK6 A0A029HEK6 A0A029IHZ1 A0A029IHZ1 A0A029IHZ1 A0A069QB72 A0A069QB72 A0A069QB72 A0A069QB72
    (1554 more...)
    Enoyl-CoA hydratase. [EC: 4.2.1.17]
    (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O.
    • Acts in the reverse direction.
    • With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).
    1564 A0A029HEK6 A0A029HEK6 A0A029HEK6 A0A029IHZ1 A0A029IHZ1 A0A029IHZ1 A0A069QB72 A0A069QB72 A0A069QB72 A0A069QB72
    (1554 more...)