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CATH Superfamily 3.90.199.10

Topoisomerase II, domain 5

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Topoisomerase II, domain 5
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: DNA topoisomerase 2

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA topoisomerase (ATP-hydrolyzing). [EC: 5.6.2.3]
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
  • The enzyme can introduce negative superhelical turns into double- stranded circular DNA.
  • One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2).
  • Formerly EC 5.99.1.3.
 34 A0A098KXG8 A0A098KXG8 A0A178VFD9 A0A178VFD9 A0A480JS00 A0A480JS00 G3I5N5 G3I5N5 O42130 O42131
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