The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Protein tyrosine phosphatase superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 49: Dual specificity protein phosphatase 14

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 O95147 (/IPI) O95147 (/IPI) O95147 (/IPI) O95147 (/IPI) O95147 (/IPI) O95147 (/IPI) O95147 (/IPI) O95147 (/IPI) O95147 (/IPI) Q9H596 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
9 O95147 (/HDA) O95147 (/HDA) O95147 (/HDA) O95147 (/HDA) O95147 (/HDA) O95147 (/HDA) O95147 (/HDA) O95147 (/HDA) O95147 (/HDA)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
5 Q5BIP9 (/ISS) Q5R8X2 (/ISS) Q6AXW7 (/ISS) Q8VE01 (/ISS) Q9D9D8 (/ISS)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
4 Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q9H596 (/IDA)
Protein tyrosine/serine/threonine phosphatase activity GO:0008138
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
4 Q5BIP9 (/ISS) Q5R8X2 (/ISS) Q6AXW7 (/ISS) Q8VE01 (/ISS)
Protein tyrosine/serine/threonine phosphatase activity GO:0008138
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
3 Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q8NEJ0 (/IDA)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
3 Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q8NEJ0 (/IDA)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 Q8VE01 (/ISO)
Protein tyrosine/serine/threonine phosphatase activity GO:0008138
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 Q8VE01 (/ISO)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 Q8VE01 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
4 Q5BIP9 (/ISS) Q5R8X2 (/ISS) Q6AXW7 (/ISS) Q8VE01 (/ISS)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
4 Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q9H596 (/IDA)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
4 Q5BIP9 (/ISS) Q5R8X2 (/ISS) Q6AXW7 (/ISS) Q8VE01 (/ISS)
Peptidyl-threonine dephosphorylation GO:0035970
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
4 Q5BIP9 (/ISS) Q5R8X2 (/ISS) Q6AXW7 (/ISS) Q8VE01 (/ISS)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
3 Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q8NEJ0 (/IDA)
Peptidyl-threonine dephosphorylation GO:0035970
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
3 Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q8NEJ0 (/IDA)
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
2 Q8VE01 (/ISS) Q9D9D8 (/ISS)
Protein targeting to mitochondrion GO:0006626
The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.
2 Q8VE01 (/ISS) Q9D9D8 (/ISS)
Protein localization to organelle GO:0033365
A process in which a protein is transported to, or maintained in, a location within an organelle.
2 Q8VE01 (/ISS) Q9D9D8 (/ISS)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 Q8VE01 (/ISO)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
1 Q8VE01 (/ISO)
Peptidyl-threonine dephosphorylation GO:0035970
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
1 Q8VE01 (/ISO)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 Q8VE01 (/ISS)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
8 A0A024R1L2 (/IDA) A0A024R1L2 (/IDA) A0A024R1L2 (/IDA) F8VX42 (/IDA) F8VX42 (/IDA) Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q8NEJ0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 Q5BIP9 (/ISS) Q5R8X2 (/ISS) Q6AXW7 (/ISS) Q8VE01 (/ISS) Q9JLY7 (/ISS) Q9JLY7 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q5BIP9 (/ISS) Q5R8X2 (/ISS) Q8VE01 (/ISS) Q9JLY7 (/ISS) Q9JLY7 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q9H596 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q8NEJ0 (/IDA) Q9H596 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q8VE01 (/ISS) Q9D9D8 (/ISS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 Q8VE01 (/ISS) Q9D9D8 (/ISS)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
2 Q8VE01 (/ISS) Q9D9D8 (/ISS)
Extrinsic component of mitochondrial inner membrane GO:0031314
The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
2 D3ZAQ8 (/IDA) Q6AXW7 (/IDA)
Extrinsic component of mitochondrial inner membrane GO:0031314
The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
2 Q8VE01 (/ISO) Q9D9D8 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8VE01 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8VE01 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8VE01 (/ISO)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
1 Q6AXW7 (/IDA)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
1 Q8VE01 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 D3ZAQ8 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q9D9D8 (/ISO)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q9D9D8 (/ISS)
Intrinsic component of mitochondrial inner membrane GO:0031304
The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 Q8VE01 (/ISS)
Extrinsic component of mitochondrial inner membrane GO:0031314
The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q8VE01 (/ISS)
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