The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Protein tyrosine phosphatase superfamily
".
FunFam 48: dual specificity protein phosphatase 22 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|
6 | Q99N11 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) |
|
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
|
6 | Q99N11 (/IPI) Q9NRW4 (/IPI) Q9NRW4 (/IPI) Q9NRW4 (/IPI) Q9NRW4 (/IPI) Q9NRW4 (/IPI) |
|
Non-membrane spanning protein tyrosine phosphatase activity GO:0004726
Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
|
5 | Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) |
|
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|
1 | Q99N11 (/ISO) |
|
Non-membrane spanning protein tyrosine phosphatase activity GO:0004726
Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
|
1 | Q99N11 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q99N11 (/IPI) |
|
Protein tyrosine/serine/threonine phosphatase activity GO:0008138
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|
1 | Q99N11 (/ISO) |
|
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
|
1 | Q99N11 (/ISO) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
5 | Q9NRW4 (/IMP) Q9NRW4 (/IMP) Q9NRW4 (/IMP) Q9NRW4 (/IMP) Q9NRW4 (/IMP) |
|
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
5 | Q9NRW4 (/IMP) Q9NRW4 (/IMP) Q9NRW4 (/IMP) Q9NRW4 (/IMP) Q9NRW4 (/IMP) |
|
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
|
5 | Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) |
|
Negative regulation of focal adhesion assembly GO:0051895
Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
|
5 | Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) |
|
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
|
5 | Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) |
|
Negative regulation of non-membrane spanning protein tyrosine kinase activity GO:1903996
Any process that stops, prevents or reduces the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.
|
5 | Q9NRW4 (/IMP) Q9NRW4 (/IMP) Q9NRW4 (/IMP) Q9NRW4 (/IMP) Q9NRW4 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q99N11 (/ISO) |
|
Negative regulation of T cell mediated immunity GO:0002710
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.
|
1 | Q99N11 (/IMP) |
|
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q99N11 (/IMP) |
|
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
1 | Q99N11 (/ISO) |
|
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
|
1 | Q99N11 (/ISO) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
1 | Q99N11 (/IMP) |
|
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | Q99N11 (/IDA) |
|
Negative regulation of T cell receptor signaling pathway GO:0050860
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
|
1 | Q99N11 (/IMP) |
|
Negative regulation of T cell activation GO:0050868
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.
|
1 | Q99N11 (/IMP) |
|
Negative regulation of focal adhesion assembly GO:0051895
Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
|
1 | Q99N11 (/ISO) |
|
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
|
1 | Q99N11 (/ISO) |
|
Negative regulation of non-membrane spanning protein tyrosine kinase activity GO:1903996
Any process that stops, prevents or reduces the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.
|
1 | Q99N11 (/ISO) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) |
|
Filamentous actin GO:0031941
A two-stranded helical polymer of the protein actin.
|
5 | Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) |
|
Leading edge of lamellipodium GO:0061851
That part of the lamellipodium which represents the distal part of the structure.
|
5 | Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) Q9NRW4 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q99N11 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q99N11 (/ISO) |
|
Filamentous actin GO:0031941
A two-stranded helical polymer of the protein actin.
|
1 | Q99N11 (/ISO) |
|
Leading edge of lamellipodium GO:0061851
That part of the lamellipodium which represents the distal part of the structure.
|
1 | Q99N11 (/ISO) |
