The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Protein tyrosine phosphatase superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 37: dual specificity protein phosphatase 26

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein tyrosine/serine/threonine phosphatase activity GO:0008138
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
18 A4IHU7 (/ISS) P0C591 (/ISS) P0C592 (/ISS) P0C593 (/ISS) P0C594 (/ISS) P0C594 (/ISS) P0C595 (/ISS) P0C596 (/ISS) P0C597 (/ISS) P0C598 (/ISS)
(8 more)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
8 Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
8 Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI)
Phosphoserine phosphatase activity GO:0004647
Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate.
8 Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA)
Phosphoserine phosphatase activity GO:0004647
Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate.
8 Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP)
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
8 Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
8 Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI) Q9BV47 (/IPI)
Protein tyrosine/serine/threonine phosphatase activity GO:0008138
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
2 Q68J44 (/IDA) Q6B8I0 (/IDA)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
1 Q9D700 (/ISO)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
1 Q9D700 (/ISO)
Phosphoserine phosphatase activity GO:0004647
Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate.
1 Q9D700 (/ISO)
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
1 Q9D700 (/ISO)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 Q9D700 (/ISO)
Protein tyrosine/serine/threonine phosphatase activity GO:0008138
Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 Q8BK84 (/ISO)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 Q6B8I1 (/IDA)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 Q6B8I0 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q68J44 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8BK84 (/ISO)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
18 A4IHU7 (/ISS) P0C591 (/ISS) P0C592 (/ISS) P0C593 (/ISS) P0C594 (/ISS) P0C594 (/ISS) P0C595 (/ISS) P0C596 (/ISS) P0C597 (/ISS) P0C598 (/ISS)
(8 more)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
9 Q68J44 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
8 Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA)
Negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0044387
The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase.
8 Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
8 Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP) Q9BV47 (/IMP)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
8 Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA)
Positive regulation of peptidyl-serine dephosphorylation GO:1902310
Any process that activates or increases the frequency, rate or extent of peptidyl-serine dephosphorylation.
8 Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
2 Q8BK84 (/ISO) Q9D700 (/ISO)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9D700 (/ISO)
Skeletal myofibril assembly GO:0014866
The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.
1 F1QWM2 (/IMP)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 Q6B8I1 (/IDA)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 Q6B8I0 (/ISO)
Negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0044387
The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase.
1 Q9D700 (/ISO)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 Q9D700 (/ISO)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q9D700 (/ISO)
Positive regulation of peptidyl-serine dephosphorylation GO:1902310
Any process that activates or increases the frequency, rate or extent of peptidyl-serine dephosphorylation.
1 Q9D700 (/ISO)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 Q6B8I1 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
8 Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA) Q9BV47 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
8 Q9BV47 (/HDA) Q9BV47 (/HDA) Q9BV47 (/HDA) Q9BV47 (/HDA) Q9BV47 (/HDA) Q9BV47 (/HDA) Q9BV47 (/HDA) Q9BV47 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q6B8I0 (/ISO) Q9D700 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9D700 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9D700 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9D700 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9D700 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q9D700 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q68J44 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q8BK84 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...