The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Protein tyrosine phosphatase superfamily
".
FunFam 23: Tyrosine-protein phosphatase non-receptor type
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 13 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P26045 (/IPI) P29074 (/IPI) P29074 (/IPI) Q9WU22 (/IPI) |
|
Non-membrane spanning protein tyrosine phosphatase activity GO:0004726
Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
|
2 | P29074 (/TAS) P29074 (/TAS) |
|
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
|
1 | P26045 (/IPI) |
|
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
|
1 | A2ALK8 (/ISO) |
|
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|
1 | P26045 (/IDA) |
|
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|
1 | A2ALK8 (/ISO) |
|
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|
1 | A2ALK8 (/ISS) |
|
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|
1 | P26045 (/TAS) |
|
Non-membrane spanning protein tyrosine phosphatase activity GO:0004726
Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
|
1 | Q9WU22 (/IDA) |
|
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
|
1 | P26045 (/IDA) |
|
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
|
1 | A2ALK8 (/ISO) |
|
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
|
1 | P26045 (/IPI) |
|
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
|
1 | A2ALK8 (/ISO) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
|
3 | P26045 (/TAS) P29074 (/TAS) P29074 (/TAS) |
|
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
2 | P29074 (/TAS) P29074 (/TAS) |
|
Liver regeneration GO:0097421
The regrowth of lost or destroyed liver.
|
2 | A0A096MJT2 (/IEP) F1LQQ5 (/IEP) |
|
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
|
1 | P26045 (/IDA) |
|
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
|
1 | A2ALK8 (/ISO) |
|
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
1 | P26045 (/TAS) |
|
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
|
1 | P26045 (/IDA) |
|
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
|
1 | A2ALK8 (/ISO) |
|
Negative regulation of membrane protein ectodomain proteolysis GO:0051045
Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.
|
1 | P26045 (/IMP) |
|
Negative regulation of membrane protein ectodomain proteolysis GO:0051045
Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.
|
1 | A2ALK8 (/ISO) |
|
Regulation of membrane depolarization during action potential GO:0098902
Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential.
|
1 | P26045 (/IDA) |
|
Regulation of membrane depolarization during action potential GO:0098902
Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential.
|
1 | A2ALK8 (/ISO) |
|
Regulation of sodium ion transmembrane transporter activity GO:2000649
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.
|
1 | P26045 (/IDA) |
|
Regulation of sodium ion transmembrane transporter activity GO:2000649
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.
|
1 | A2ALK8 (/ISO) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | P26045 (/IDA) P29074 (/IDA) P29074 (/IDA) |
|
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
3 | P26045 (/IDA) P29074 (/IDA) P29074 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | P29074 (/TAS) P29074 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | A2ALK8 (/ISO) Q9WU22 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P29074 (/TAS) P29074 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P29074 (/TAS) P29074 (/TAS) |
|
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
2 | A2ALK8 (/ISO) Q9WU22 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P26045 (/TAS) |
|
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
|
1 | P28191 (/HDA) |
