The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Protein tyrosine phosphatase superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 162: Tyrosine-protein phosphatase vhp-1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
JUN kinase phosphatase activity GO:0008579
Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate.
1 Q10038 (/IDA)
MAP kinase tyrosine/serine/threonine phosphatase activity GO:0017017
Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate.
1 Q10038 (/IDA)
Mitogen-activated protein kinase binding GO:0051019
Interacting selectively and non-covalently with a mitogen-activated protein kinase.
1 Q10038 (/IPI)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 Q10038 (/IGI)
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
1 Q10038 (/IDA)
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
1 Q10038 (/IGI)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 Q10038 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q10038 (/IMP)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 Q10038 (/IDA)
Response to unfolded protein GO:0006986
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
1 Q10038 (/IGI)
Response to unfolded protein GO:0006986
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
1 Q10038 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q10038 (/IMP)
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q10038 (/IDA)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q10038 (/IGI)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q10038 (/IMP)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
1 Q10038 (/IGI)
Negative regulation of axon extension involved in regeneration GO:0048692
Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in regeneration.
1 Q10038 (/IMP)
Regulation of protein localization to nucleus GO:1900180
Any process that modulates the frequency, rate or extent of protein localization to nucleus.
1 Q10038 (/IGI)
Negative regulation of protein localization to nucleus GO:1900181
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.
1 Q10038 (/IMP)
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
1 Q10038 (/IMP)
Negative regulation of defense response to bacterium GO:1900425
Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.
1 Q10038 (/IGI)
Negative regulation of defense response to bacterium GO:1900425
Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.
1 Q10038 (/IMP)
Positive regulation of defense response to bacterium GO:1900426
Any process that activates or increases the frequency, rate or extent of defense response to bacterium.
1 Q10038 (/IGI)
Positive regulation of defense response to bacterium GO:1900426
Any process that activates or increases the frequency, rate or extent of defense response to bacterium.
1 Q10038 (/IMP)
Negative regulation of stress response to copper ion GO:1903854
Any process that stops, prevents or reduces the frequency, rate or extent of stress response to copper ion.
1 Q10038 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q10038 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q10038 (/ISS)
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