The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Protein tyrosine phosphatase superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: protein tyrosine phosphatase type IVA 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Prenylated protein tyrosine phosphatase activity GO:0004727
Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate.
91 O75365 (/TAS) O75365 (/TAS) O75365 (/TAS) O75365 (/TAS) O75365 (/TAS) O75365 (/TAS) O75365 (/TAS) O75365 (/TAS) O75365 (/TAS) O75365 (/TAS)
(81 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
46 O75365 (/IPI) O75365 (/IPI) O75365 (/IPI) O75365 (/IPI) O75365 (/IPI) O75365 (/IPI) O75365 (/IPI) O75365 (/IPI) O75365 (/IPI) O75365 (/IPI)
(36 more)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
35 Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA)
(25 more)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
35 Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO)
(25 more)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
35 Q93096 (/NAS) Q93096 (/NAS) Q93096 (/NAS) Q93096 (/NAS) Q93096 (/NAS) Q93096 (/NAS) Q93096 (/NAS) Q93096 (/NAS) Q93096 (/NAS) Q93096 (/NAS)
(25 more)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
45 Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS)
(35 more)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
35 Q63739 (/IDA) Q63739 (/IDA) Q63739 (/IDA) Q63739 (/IDA) Q63739 (/IDA) Q63739 (/IDA) Q63739 (/IDA) Q63739 (/IDA) Q63739 (/IDA) Q63739 (/IDA)
(25 more)
Endothelial cell migration GO:0043542
The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
13 O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP)
(3 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
11 O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA)
(1 more)
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
11 O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA) O75365 (/IDA)
(1 more)
Positive regulation of establishment of protein localization GO:1904951
Any process that activates or increases the frequency, rate or extent of establishment of protein localization.
11 O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP)
(1 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 Q9D658 (/ISO) Q9D658 (/ISO)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q9D658 (/IDA) Q9D658 (/IDA)
Positive regulation of vascular permeability GO:0043117
Any process that increases the extent to which blood vessels can be pervaded by fluid.
2 Q9D658 (/IMP) Q9D658 (/IMP)
Endothelial cell migration GO:0043542
The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
2 Q9D658 (/ISO) Q9D658 (/ISO)
Regulation of vascular endothelial growth factor signaling pathway GO:1900746
Any process that modulates the frequency, rate or extent of vascular endothelial growth factor signaling pathway.
2 Q9D658 (/IMP) Q9D658 (/IMP)
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
2 Q9D658 (/ISO) Q9D658 (/ISO)
Positive regulation of establishment of protein localization GO:1904951
Any process that activates or increases the frequency, rate or extent of establishment of protein localization.
2 Q9D658 (/ISO) Q9D658 (/ISO)
Cellular response to leukemia inhibitory factor GO:1990830
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
2 Q9D658 (/IEP) Q9D658 (/IEP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
82 O70274 (/ISO) O70274 (/ISO) O70274 (/ISO) O70274 (/ISO) O70274 (/ISO) O70274 (/ISO) O70274 (/ISO) O70274 (/ISO) O70274 (/ISO) O70274 (/ISO)
(72 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
80 Q12974 (/IDA) Q12974 (/IDA) Q12974 (/IDA) Q12974 (/IDA) Q12974 (/IDA) Q12974 (/IDA) Q12974 (/IDA) Q12974 (/IDA) Q12974 (/IDA) Q12974 (/IDA)
(70 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
45 Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS) Q12974 (/TAS)
(35 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
37 Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO)
(27 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
35 Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA) Q78EG7 (/IDA)
(25 more)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
35 Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS)
(25 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
35 Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS) Q63739 (/TAS)
(25 more)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
35 Q93096 (/IDA) Q93096 (/IDA) Q93096 (/IDA) Q93096 (/IDA) Q93096 (/IDA) Q93096 (/IDA) Q93096 (/IDA) Q93096 (/IDA) Q93096 (/IDA) Q93096 (/IDA)
(25 more)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
35 Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO) Q63739 (/ISO)
(25 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
11 O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP) O75365 (/IMP)
(1 more)
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