The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Medium-chain alcohol dehydrogenases, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Alcohol dehydrogenase AdhP

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Alcohol dehydrogenase (NAD) activity GO:0004022
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
34 P00330 (/IDA) P00331 (/IDA) P00331 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA)
(24 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
19 P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA)
(9 more)
Alcohol dehydrogenase (NAD) activity GO:0004022
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
11 A0A1D8PP43 (/ISS) P38113 (/ISS) P38113 (/ISS) P38113 (/ISS) P38113 (/ISS) P38113 (/ISS) P38113 (/ISS) P38113 (/ISS) P38113 (/ISS) P38113 (/ISS)
(1 more)
Alcohol dehydrogenase (NAD) activity GO:0004022
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
3 P07754 (/RCA) P08843 (/RCA) P54202 (/RCA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 A0A1D8PP43 (/IPI) P00330 (/IPI) Q9UAT1 (/IPI)
Alcohol dehydrogenase (NAD) activity GO:0004022
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
2 P00332 (/IMP) P08843 (/IMP)
Methylglyoxal reductase (NADH-dependent) activity GO:0019170
Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+.
2 A0A1D8PP43 (/IDA) P00330 (/IDA)
Alcohol dehydrogenase (NAD) activity GO:0004022
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
1 A0A1D8PP43 (/IGI)
Alcohol dehydrogenase (NAD) activity GO:0004022
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
1 P54202 (/ISA)
Carbonyl reductase (NADPH) activity GO:0004090
Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.
1 G8BGN6 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P00330 (/IPI)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Amino acid catabolic process to alcohol via Ehrlich pathway GO:0000947
The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
23 P00330 (/IGI) P00331 (/IGI) P00331 (/IGI) P07246 (/IGI) P07246 (/IGI) P07246 (/IGI) P07246 (/IGI) P07246 (/IGI) P07246 (/IGI) P07246 (/IGI)
(13 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
19 P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP)
(9 more)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
19 P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP) P39451 (/IEP)
(9 more)
Acetaldehyde catabolic process GO:0046187
The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol.
19 P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA) P39451 (/IDA)
(9 more)
NADH oxidation GO:0006116
A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD.
13 P00330 (/IDA) P00331 (/IDA) P00331 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA)
(3 more)
Ethanol biosynthetic process involved in glucose fermentation to ethanol GO:0043458
The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, as part of the process of glucose catabolism to ethanol, CO2 and ATP.
12 P00330 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP)
(2 more)
NADH oxidation GO:0006116
A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD.
11 P00330 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP) P38113 (/IMP)
(1 more)
Alcohol metabolic process GO:0006066
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
3 P07754 (/RCA) P08843 (/RCA) P54202 (/RCA)
Glycerol metabolic process GO:0006071
The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
3 P07754 (/RCA) P08843 (/RCA) P54202 (/RCA)
Oxalate metabolic process GO:0033609
The chemical reactions and pathways involving oxalate, the organic acid ethanedioate.
3 P07754 (/RCA) P08843 (/RCA) P54202 (/RCA)
Ethanol metabolic process GO:0006067
The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
2 P00331 (/IDA) P00331 (/IDA)
Alcohol metabolic process GO:0006066
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
1 P54202 (/IDA)
Ethanol catabolic process GO:0006068
The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
1 P08843 (/IDA)
Ethanol catabolic process GO:0006068
The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
1 P08843 (/IEP)
Threonine catabolic process GO:0006567
The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
1 P08843 (/IEP)
Threonine catabolic process GO:0006567
The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
1 P08843 (/IMP)
Ethanol biosynthetic process involved in glucose fermentation to ethanol GO:0043458
The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, as part of the process of glucose catabolism to ethanol, CO2 and ATP.
1 P00332 (/IGI)
Single-species biofilm formation on inanimate substrate GO:0044011
A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.
1 A0A1D8PP43 (/IMP)
Single-species biofilm formation in or on host organism GO:0044407
A process in which microorganisms of the same species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the microorganisms' growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 A0A1D8PP43 (/IMP)
Induction by symbiont of host defense response GO:0044416
The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 A0A1D8PP43 (/IDA)
Acetaldehyde catabolic process GO:0046187
The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol.
1 P08843 (/IEP)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q17334 (/IMP)
Interaction with host GO:0051701
An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.
1 A0A1D8PP43 (/IPI)
Cellular response to farnesol GO:0097308
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus.
1 P08843 (/IEP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 P00331 (/HDA) P00331 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA)
(3 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 P38113 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA) P38113 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 P07246 (/HDA) P07246 (/HDA) P07246 (/HDA) P07246 (/HDA) P07246 (/HDA) P07246 (/HDA) P07246 (/HDA) P07246 (/HDA) P07246 (/HDA) P07246 (/HDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
10 P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA) P07246 (/IDA)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
3 A0A1D8PP43 (/IDA) O94038 (/IDA) O94038 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q6FQA4 (/IDA) Q6FQA4 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 A0A1D8PP43 (/IDA) G8BGN6 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 A0A1D8PP43 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P00330 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P00330 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 A0A1D8PP43 (/IDA)
Fungal-type cell wall GO:0009277
A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure.
1 A0A1D8PP43 (/IDA)
Yeast-form cell wall GO:0030445
The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form.
1 A0A1D8PP43 (/IDA)
Hyphal cell wall GO:0030446
The cell wall surrounding a fungal hypha.
1 A0A1D8PP43 (/IDA)
Striated muscle dense body GO:0055120
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
1 Q9UAT1 (/HDA)