The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Hect, E3 ligase catalytic domains
".
FunFam 8: Putative ubiquitin-protein ligase E3A
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | O08759 (/IPI) Q05086 (/IPI) Q05086 (/IPI) Q05086 (/IPI) Q05086 (/IPI) Q05086 (/IPI) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
6 | Q05086 (/IMP) Q05086 (/IMP) Q05086 (/IMP) Q05086 (/IMP) Q05086 (/IMP) Q9VTH1 (/IMP) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
5 | Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
2 | O08759 (/IDA) Q9VTH1 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | O08759 (/IDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | O08759 (/ISO) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | O08759 (/ISS) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | O08759 (/ISO) |
There are 46 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
6 | O08759 (/IMP) Q05086 (/IMP) Q05086 (/IMP) Q05086 (/IMP) Q05086 (/IMP) Q05086 (/IMP) |
|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
5 | Q05086 (/TAS) Q05086 (/TAS) Q05086 (/TAS) Q05086 (/TAS) Q05086 (/TAS) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
5 | Q05086 (/TAS) Q05086 (/TAS) Q05086 (/TAS) Q05086 (/TAS) Q05086 (/TAS) |
|
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
5 | Q05086 (/TAS) Q05086 (/TAS) Q05086 (/TAS) Q05086 (/TAS) Q05086 (/TAS) |
|
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
5 | Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) |
|
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
|
5 | Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) |
|
Progesterone receptor signaling pathway GO:0050847
Any series of molecular signals generated as a consequence of a progesterone binding to its receptor.
|
5 | Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
5 | Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) |
|
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
|
5 | Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) Q05086 (/IDA) |
|
Regulation of ubiquitin-dependent protein catabolic process GO:2000058
Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
|
5 | Q05086 (/IMP) Q05086 (/IMP) Q05086 (/IMP) Q05086 (/IMP) Q05086 (/IMP) |
|
Response to cocaine GO:0042220
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
|
2 | A0A0G2JTH7 (/IEP) F1M7B8 (/IEP) |
|
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
2 | A0A0G2JTH7 (/IEP) F1M7B8 (/IEP) |
|
Negative regulation of dendritic spine morphogenesis GO:0061002
Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
2 | A0A0G2JTH7 (/IMP) F1M7B8 (/IMP) |
|
Cellular response to brain-derived neurotrophic factor stimulus GO:1990416
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus.
|
2 | A0A0G2JTH7 (/IEP) F1M7B8 (/IEP) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
1 | Q9VTH1 (/IMP) |
|
Ovarian follicle development GO:0001541
The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
|
1 | O08759 (/IMP) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | O08759 (/IDA) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | Q9VTH1 (/IMP) |
|
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
1 | Q9VTH1 (/IMP) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | Q9VTH1 (/IMP) |
|
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
1 | O08759 (/IMP) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | O08759 (/IDA) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
1 | Q9VTH1 (/IGI) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
1 | Q9VTH1 (/IMP) |
|
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
|
1 | O08759 (/IPI) |
|
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
1 | O08759 (/ISO) |
|
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
|
1 | O08759 (/ISO) |
|
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
|
1 | O08759 (/ISS) |
|
Sperm entry GO:0035037
An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur.
|
1 | O08759 (/IMP) |
|
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
|
1 | Q9VTH1 (/IMP) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | O08759 (/ISO) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | Q9VTH1 (/IDA) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | Q9VTH1 (/IGI) |
|
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
|
1 | Q9VTH1 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | O08759 (/IGI) |
|
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
|
1 | Q9VTH1 (/IMP) |
|
Peripheral nervous system neuron development GO:0048935
The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
|
1 | Q9VTH1 (/IMP) |
|
Progesterone receptor signaling pathway GO:0050847
Any series of molecular signals generated as a consequence of a progesterone binding to its receptor.
|
1 | O08759 (/ISO) |
|
Progesterone receptor signaling pathway GO:0050847
Any series of molecular signals generated as a consequence of a progesterone binding to its receptor.
|
1 | O08759 (/ISS) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
1 | O08759 (/ISO) |
|
Prostate gland growth GO:0060736
The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state.
|
1 | O08759 (/IMP) |
|
Negative regulation of dendritic spine morphogenesis GO:0061002
Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | O08759 (/ISO) |
|
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
|
1 | O08759 (/ISO) |
|
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
|
1 | O08759 (/ISS) |
|
Regulation of ubiquitin-dependent protein catabolic process GO:2000058
Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
|
1 | O08759 (/ISO) |
|
Regulation of ubiquitin-dependent protein catabolic process GO:2000058
Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
|
1 | O08759 (/ISS) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | O08759 (/IDA) Q9VTH1 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O08759 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9VTH1 (/IDA) |