The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Hect, E3 ligase catalytic domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 6: E3 ubiquitin-protein ligase TRIP12 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
5 B4F6W9 (/ISS) E1B7Q7 (/ISS) F1LP64 (/ISS) F1RCR6 (/ISS) G5E870 (/ISS)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
1 Q14669 (/IDA)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
1 Q14669 (/IMP)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
1 G5E870 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q14669 (/IPI)
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
1 Q14669 (/IDA)
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
1 G5E870 (/ISO)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
5 B4F6W9 (/ISS) E1B7Q7 (/ISS) F1LP64 (/ISS) F1RCR6 (/ISS) G5E870 (/ISS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
5 B4F6W9 (/ISS) E1B7Q7 (/ISS) F1LP64 (/ISS) F1RCR6 (/ISS) G5E870 (/ISS)
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
5 B4F6W9 (/ISS) E1B7Q7 (/ISS) F1LP64 (/ISS) F1RCR6 (/ISS) Q14669 (/ISS)
Negative regulation of histone H2A K63-linked ubiquitination GO:1901315
Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination.
5 B4F6W9 (/ISS) E1B7Q7 (/ISS) F1LP64 (/ISS) F1RCR6 (/ISS) G5E870 (/ISS)
Negative regulation of double-strand break repair GO:2000780
Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair.
5 B4F6W9 (/ISS) E1B7Q7 (/ISS) F1LP64 (/ISS) F1RCR6 (/ISS) G5E870 (/ISS)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
1 Q14669 (/TAS)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
1 Q14669 (/IDA)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
1 Q14669 (/IMP)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
1 G5E870 (/ISO)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 Q14669 (/IMP)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 G5E870 (/ISO)
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
1 G5E870 (/IMP)
Negative regulation of histone H2A K63-linked ubiquitination GO:1901315
Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination.
1 Q14669 (/IMP)
Negative regulation of histone H2A K63-linked ubiquitination GO:1901315
Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination.
1 G5E870 (/ISO)
Negative regulation of double-strand break repair GO:2000780
Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair.
1 Q14669 (/IMP)
Negative regulation of double-strand break repair GO:2000780
Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair.
1 G5E870 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 B4F6W9 (/ISS) E1B7Q7 (/ISS) F1LP64 (/ISS) F1RCR6 (/ISS) G5E870 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q14669 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q14669 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 G5E870 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q14669 (/TAS)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q14669 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 G5E870 (/ISO)