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CATH Superfamily 3.90.1580.10

paralog of FGE (formylglycine-generating enzyme)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
paralog of FGE (formylglycine-generating enzyme)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Generic methyltransferase, putative

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
L-histidine N(alpha)-methyltransferase. [EC: 2.1.1.44]
3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine.
  • Part of the biosynthetic pathway of ergothioneine.
 1 O94632
Hercynylcysteine S-oxide synthase. [EC: 1.14.99.51]
Hercynine + L-cysteine + O(2) = S-hercyn-2-yl-L-cysteine S-oxide + H(2)O.
  • The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44.
  • It is part of the biosynthesis pathway of ergothioneine.
  • The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine.
 1 O94632