The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Argininosuccinate synthetase, chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Argininosuccinate synthase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Argininosuccinate synthase activity GO:0004055
Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.
9 P22768 (/IDA) P22768 (/IDA) P22768 (/IDA) P22768 (/IDA) P22768 (/IDA) P22768 (/IDA) P22768 (/IDA) P22768 (/IDA) P22768 (/IDA)
Argininosuccinate synthase activity GO:0004055
Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.
2 A0A1D8PRR5 (/NAS) A0A1D8PRR5 (/NAS)
Argininosuccinate synthase activity GO:0004055
Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.
1 O94354 (/IMP)
Argininosuccinate synthase activity GO:0004055
Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.
1 C8VKI3 (/RCA)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Arginine biosynthetic process GO:0006526
The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
12 A0A1D8PRR5 (/IMP) A0A1D8PRR5 (/IMP) O94354 (/IMP) P22768 (/IMP) P22768 (/IMP) P22768 (/IMP) P22768 (/IMP) P22768 (/IMP) P22768 (/IMP) P22768 (/IMP)
(2 more)
Urea cycle GO:0000050
The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
1 O94354 (/IC)
Argininosuccinate metabolic process GO:0000053
The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate.
1 O94354 (/ISO)
Arginine metabolic process GO:0006525
The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
1 C8VKI3 (/RCA)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 P22768 (/IDA) P22768 (/IDA) P22768 (/IDA) P22768 (/IDA) P22768 (/IDA) P22768 (/IDA) P22768 (/IDA) P22768 (/IDA) P22768 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O94354 (/HDA)
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