The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Aspartate Aminotransferase, domain 1
".
FunFam 81: serine palmitoyltransferase 1 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Serine C-palmitoyltransferase activity GO:0004758
Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.
|
6 | O54695 (/ISS) O54695 (/ISS) Q3MHG1 (/ISS) Q5R9T5 (/ISS) Q5R9T5 (/ISS) Q60HD1 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | O15269 (/IPI) O15269 (/IPI) O35704 (/IPI) |
|
Serine C-palmitoyltransferase activity GO:0004758
Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.
|
2 | O15269 (/IDA) O15269 (/IDA) |
|
Serine C-palmitoyltransferase activity GO:0004758
Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.
|
2 | O15269 (/TAS) O15269 (/TAS) |
|
Serine C-palmitoyltransferase activity GO:0004758
Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.
|
1 | O35704 (/IMP) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of fat cell apoptotic process GO:1904649
Any process that modulates the frequency, rate or extent of fat cell apoptotic process.
|
8 | O15269 (/ISS) O15269 (/ISS) O54695 (/ISS) O54695 (/ISS) Q3MHG1 (/ISS) Q5R9T5 (/ISS) Q5R9T5 (/ISS) Q60HD1 (/ISS) |
|
Sphingolipid metabolic process GO:0006665
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
|
4 | Q3MHG1 (/ISS) Q5R9T5 (/ISS) Q5R9T5 (/ISS) Q60HD1 (/ISS) |
|
Sphingomyelin biosynthetic process GO:0006686
The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
|
3 | O35704 (/IDA) O54695 (/IDA) O54695 (/IDA) |
|
Sphingolipid metabolic process GO:0006665
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
|
2 | O15269 (/TAS) O15269 (/TAS) |
|
Sphingolipid biosynthetic process GO:0030148
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
|
2 | O15269 (/IDA) O15269 (/IDA) |
|
Sphingolipid biosynthetic process GO:0030148
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
|
2 | O15269 (/TAS) O15269 (/TAS) |
|
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
|
2 | O15269 (/IDA) O15269 (/IDA) |
|
Positive regulation of lipophagy GO:1904504
Any process that activates or increases the frequency, rate or extent of lipophagy.
|
2 | O15269 (/IDA) O15269 (/IDA) |
|
Sphingolipid metabolic process GO:0006665
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
|
1 | O35704 (/IMP) |
|
Sphingomyelin biosynthetic process GO:0006686
The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
|
1 | O35704 (/IMP) |
|
Sphingomyelin biosynthetic process GO:0006686
The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
|
1 | O35704 (/ISA) |
|
Sphingolipid biosynthetic process GO:0030148
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
|
1 | O35704 (/ISO) |
|
Sphinganine biosynthetic process GO:0046511
The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol.
|
1 | O35704 (/IMP) |
|
Sphingosine biosynthetic process GO:0046512
The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
|
1 | O35704 (/IMP) |
|
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
|
1 | O35704 (/IMP) |
|
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
|
1 | O35704 (/ISO) |
|
Positive regulation of lipophagy GO:1904504
Any process that activates or increases the frequency, rate or extent of lipophagy.
|
1 | O35704 (/ISO) |
|
Regulation of fat cell apoptotic process GO:1904649
Any process that modulates the frequency, rate or extent of fat cell apoptotic process.
|
1 | O35704 (/IMP) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
SPOTS complex GO:0035339
A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis.
|
7 | O35704 (/ISS) O54695 (/ISS) O54695 (/ISS) Q3MHG1 (/ISS) Q5R9T5 (/ISS) Q5R9T5 (/ISS) Q60HD1 (/ISS) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
4 | A0A024R277 (/IDA) A0A024R277 (/IDA) O15269 (/IDA) O15269 (/IDA) |
|
Serine C-palmitoyltransferase complex GO:0017059
An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine.
|
4 | O15269 (/IDA) O15269 (/IDA) O54695 (/IDA) O54695 (/IDA) |
|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
2 | O15269 (/TAS) O15269 (/TAS) |
|
SPOTS complex GO:0035339
A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis.
|
2 | O15269 (/IDA) O15269 (/IDA) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | O35704 (/ISO) |
|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
1 | O35704 (/IDA) |
|
Serine C-palmitoyltransferase complex GO:0017059
An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine.
|
1 | O35704 (/ISA) |
|
Serine C-palmitoyltransferase complex GO:0017059
An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine.
|
1 | O35704 (/ISO) |
|
SPOTS complex GO:0035339
A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis.
|
1 | O35704 (/ISO) |
